Effect Of Immune Function Of Patients Carried Out Laparoscopic Rectal Cancer Operation By Neoadjuvant Chemoradiotherapy

Background:Colorectal cancer is a common malignant tumor of the digestive system, and its incidence increased year by year. At present, surgical resection is still the principal means of comprehensive treatment of colon cancer. In recent years, laparoscopic techniques was used in the surgical field widely, its effects on the body’s immune function was also concerned. Neoadjuvant therapy can reduce tumor load、different level reduce the clinical stage、improve the resection rate and its other merits was attention and recognition. No final conclusion has yet been reached on whether preoperative chemoradiotherapy will influencethe immune function of patients with laparoscopic surgical treatment of colorectal cancer,Objective:To study effect of immune function of patients carried out laparoscopic rectal caner operation by neoadjuvant chemoradiotherapy.Methods:The clinical data for53patients with locally advanced rectal caner who had been treated by laparoscopic operation in the general surgery department of the center Hospital of Nanyang city from January2012to June2013were retrospectively analyzed. The patients were randomly divided into neoadjuvant chemoradiotherapy. group (group A, n=26) and control group (group B, n=27), Preoperative chemoradiotherapy group with FOLFOX4chemotherapy, on day1, Oxaliplatin into injection85mg/m2, continuous intravenous drip drop2h.5-Fu400mg/m2, intravenous injection and5-Fu600mg/m2for intravenous drip22h,1d and2d;14d for the cycle, a total of2cycles. A simultaneous radiotherapy, and chemotherapy, radiation therapy for46Gy, total1time every day, every time2Gy, a total of23times. At the end of the radiation and chemotherapy after6～8weeks accepted laparoscopic assisted radical surgery for rectal cancer. Control group directly radical surgery with laparoscopic assisted colorectal cancer. Another selection during the same period health check-up volunteers in20cases of healthy controls (group C). Observing A, B two groups of patients with operation time, blood loss, postoperative infection, postoperative complications and the change of tumor size, and analysis3d after admission,1d before surgery and postoperative1d,7d extracting peripheral venous blood examination of serum IgG, IgA, C3, C4and CD3+, CD4+, CD8+, CD4+/CD8+, IL-2, CRP, CD8+, IL-4, INF-gamma, etc.,Results:The operation time, bleeding amount, infection, complications were no significant statistics(P>0.05). the IgG, IgA, C3, C4, CD8+, CD4+/CD8+,IL-2of patients in two group were lower than healthy control group.the CRP, CD8+, IL-4, INF-y were significantly increased (P<0.05)The serum IgG, IgA,C3, C4, CD3+, CD4+, CD4+/CD8+, IL-2before operation in preoperative chemoradiotherapy group were significantly higher than those at3days after admission(P<0.05),the CRP, CD8+, IL-4, INF-y were obviously lower than those at3days after admission(P<0.05), the related index were significant differences between two groups before operation (P<0.05).The IgG, IgA, C3, C4, CRP, CD3+, CD4+, CD4+/CD8+, IL-2, IL-4, INF-y at7days after operation were better than those before operation and control group(P <0.05).Conclusion:for rectal cancer patients, using neoadjuvant chemoradiotherapy before laparoscopic operation can significantly improve immune function,so as to restore immune function after operation.