The Preliminary Experience With Acoustic Structure Quantification(ASQ) Software In Estimating The Degree Of Liver Fibrosis Of Chronic Hepatitis B

Objective The aim of our study was to assess the diagnostic accuracy of acoustic structure quantification (ASQ) ultrasound software in estimating the degree of hepatic fibrosis of chronic hepatitis B compared to Fibroscan and liver biopsy.Methods Collecting66patients with histologically proven chronic hepatitis B virus,whose underwent standard ultrasoundexamination,ASQ,Fibroscan and liver biopsy. According to the pathological fibrosis stage as the gold standard, divided into five groups of S0-S4. Analysis of the original echo echo of liver parenchyma of the application of ASQ technology, analysis the values of7parameters and record:BR-Ratio (area under the curve than the blue and red), each of the3parameters of red, blue curve:Mode (mode) and Average (mean), SD (standard deviation) and analysis of Stiffness value of Fibroscan detected (liver stiffness values). The quantitative parameters and detection of Fibroscan ASQ Stiffness values were correlated with the pathological liver fibrosis indexes.For well-correlation parameter, ROC was analyzed to get the optimal cutoff value for liver fibrosis S>land S>2and S>3and S>4and confirming the cut off value of distinction between liver fibrosis stage, compared the area under the curve (AUC) between ASQ and Fibroscan.Results Along with the increase of the degree of liver fibrosis, ASQ parameter imaging color coded map showed liver parenchymal hyperechoic uneven, the Red areas increased, and irregular, reduce the yellow green region, the quantitative analysis of ASQ image shows the red curve distribution becomes narrow, rough, wider distribution, the blue line peak increases, the area under the curve increases.The quantitative parameter BR-Ratio value in each group were much larger than the other six indicators and has a good positive correlation (r=0.772, P<0.05), when S≥1、S≥2、S≥3、S≥4, The areas under ROC curves of ASQ were0.832.0.913.0.962、0.974respectively.There were significant differences in Fibroscan between each detected Stiffness value (P<0.05) and the degree-of liver fibrosis and has a good positive correlation (r=0.818, P<0.05), area when S≥1、S≥2、S≥3、S≥4, The areas under ROC curves of ASQ were0.826,0.877,0.988,0.993respectively.. The ASQ and Fibroscan in the differentiation of S>1. S≥2、S≥3、S≥4cut-off values were0.33、0.37、0.49、0.55;4.74kpa、5.62kpa、7.05kpa、14.4kpa respectively. The difference between the AUROC was statistically not significant (p>0.05).Conclusion ASQ is quantified on the basis of echo signal in a different technique for diagnosis and a good correlation with pathological grades, the diagnosis value of degree of hepatic fibrosis is similar to Fibroscan, for hepatic fibrosis staging diagnosised is feasible, has wide clinical application foreground in quantitative diagnosis of liver fibrosis.