The Value Of~18F-FDG PET/CT In The Staging Diagnosis And Metastasis Of Malignant Melanoma

Objective:To evaluate the effective and advantages of for PET/CT for N and M staging of Malignant melanoma. and assess the diagnostic value of various imaging examinations for metastasis of Malignant melanoma.Methods:A retrospective analysis of a total of114patients(69males,45females,22-98year)with AJCC stage Ⅱ～Ⅳ malignant melanoma. Diagnostic accuracy for N-and M-staging was determined for CT alone, PET alone, and PET/CT. The sensitivity, specificity, positive predictive value, negative predictive value, accuracy was study respectively. The PET/CT, PET, CT imaging results are for pairwise comparisons, the data rows of2×2χ2test To study the clinical and imaging data (6weeks after final diagnosis)of82Patients with American Joint Committee on Cancer (AJCC) stage Ⅲ and Ⅳ melanoma with symptomless,respectively account the true positive rate, false positive rate,specificity, accuracy. Imaging suspicious for metastatic lesions underwent biopsy histopathology or clinical and radiologic follow-up confirmed or excluded. The PET/CT with other imaging results were compared with the data rows of2×2χ2test exact test.Results:PET/CT detected significantly more visceral and nonvascular metastases than PET alone and CT alone (98.2%,88.4%, and71.3%, respectively). PET/CT imaging thus provided significantly more accurate interpretations regarding overall N-and M-staging than PET alone and CT alone. Overall N-and M-stage was correctly determined by PET/CT in110of114patients (96.5%) compared between PET/CT and CT as well as between PET and CT was significant (P<0.01). PET/CT, PET, CT staging overall accuracy was96.5%(110/114),91.2%(104/114),81.6%(93/114), in which PET/CT and PET, PET/CT and CT differences were statistically (P<0.05), PET and CT showed no statistical significance. A total of82patients using radiographic imaging, including ultrasound, CR, head CT, chest CT, abdomen and pelvic CT, head MRI, PET, PET/CT. Among548staging examinations in82patients,27.0%were initially reported as positive.15.3%of all examinations proved truly positive. The ratio of falsely to truly positive is approximately1.3:1, The rate of Traditional imaging, PET, PET/CT was1:1.5,2.4:1,3.8:1respectively. The specificity of the rate was77.5%,89.6%,90.9%, The accuracy of the rate was69.5 %,81.7%,87.8%.Except the comparison of PET/CT and PET have no significance (P=0.413), PET and traditional imaging, PET/CT and Traditional imaging have both significance (P<0.01)Conclusions:Compared with PET and CT, PET/CT have more accuracy in MM N stage, M stage and overall stage. PET/CT can be find more lesions[98.2%(329/335)、88.4%(296/335)、71.3%(239/335) respectively.The diagnostic performance of FDG-PET/CT for N-and M-staging of melanoma patients suggests its use for whole-body tumor staging, especially for detection or exclusion of distant metastases. PET and PET/CT have more obviously advantages in Malignant melanoma than Traditional imaging in the diagnostic value.