The Study Of Clinical Effect On Electropuncture Treatment For The Patients Of Vascular Cognitive Impairment Of Non-dementia

ObjectivesObserve the change before and after treatment on MoCA and CDR, use electropuncture to stimulate the patients of vascular cognitive impairment of non-dementia by the basis of clinical rigorous study design and mainly needling the acupoints of Intelligent Three Needles and Sishencong, to quantitative observation the neuropsychological effect of electropuncture for the patients of vascular cognitive impairment of non-dementia. And compare with Nimotop which is current widespread use of calcium antagonists, to analyze the characteristics of VCIND cognitive function. Explore the clinical efficacy of electropuncture on VCIND patients, and early intervention on VCI patients to reduce VaD incidence.MethodsAll study subjects were from the outpatient and inpatient of the No.1Affiliated Hospital of Guangzhou University of TCM. According to the diagnostic criteria, inclusion and exclusion criteria, eligible subjects were identified in40cases, patients were randomly assigned to the electropuncture group and the control group (Nimotop group) by the random number table,20patients in each group. Electropuncture group were treated with Intelligent Three Needles and Sishencong as main acupoints and the others with dialectical subtraction. Flat spines main acupoints by30th stainless steel needles of HuaTuo brand and then connect G6805-Ⅱ electropuncture device (manufactured in Shanghai) after get qi, using sparse and density wave alternately, the amount of stimulation is based on that patients can tolerate, and other acupoints are all reinforcing-reducing. The electropuncture group is treated by the same physician every morning, once a day, every ten days to rest for two days, and then continue treatment, a total of4weeks. The control group is with oral calcium antagonist Nimotop, the amount of30mg per time,3times per day for4weeks. To observe scale changes before and after treatment for patients with Montreal Cognitive Assessment (MoCA) and Clinical Dementia Rating scale (CDR), two groups were measured scores respectively before treatment, two weeks after treatment and four weeks after treatment. The last step is data entry and statistical analysis.Result1. After4weeks treatment, the electropuncture group has95%of total effective rate, the control group has70%of total effective rate, the electro-puncture group was better than control group, two groups was statistically significant (P<0.05).2. According to the MoCA scale assessment, before and after2weeks treatment and after4weeks, the electropuncture group was improved in attention, abstraction, memory and delayed memory, orientation iterms and there was a significant difference (P<0.05); the control group was improved in the memory and delayed memory iterms and there was a significant difference (P<0.05). Before treatment between the two groups, all items are comparable that the two groups showed no significant difference (P>0.05) in visual spatial and executive ability, named, attention, language, abstraction, memory and delayed memory, total score items; after2weeks treatment between the two groups, there was a significant difference (P<0.05) and the electropuncture group was higher score than the control group in visual spatial and executive ability, named sub items; after4weeks treatment between the two groups, there was significant difference (P<0.05) and the electropuncture group was higher score than the control group in attention, memory and delayed memory, abstraction, total score items.3. According to the CDR scale assessment, before and after2weeks treatment and after4weeks, the electropuncture group was improved in orientation iterms and there was a significant difference (P<0.05); the control group was improved in orientation, judgment and the ability to solve problems iterms and there was a significant difference (P<0.05). Before treatment between the two groups, all items are comparable that the two groups showed no significant difference (P>0.05). After2weeks treatment between the two groups, there was significant difference (P<0.05) and the electropuncture group was higher score than the control group in the total score iterms; after4weeks treatment between the two groups, there was a significant difference (P<0.05) and the electropuncture group was lower score than the control group in orientation, family and hobbies sub items, and there was a significant difference (P<0.05) and the electropuncture group was higher score than the control group in social affairs sub items.ConclusionUsing electropuncture to stimulate the acupoints of Intelligent Three Needles and Sishencong, and oral Nimotop treatment all can improve the cognitive function in VCIND patients, intervent on VCIND damage, reduce the degree of cognitive function, but the curative effect of electropuncture group was significantly better than control group. According to the MoCA scale assessment, electropuncture group improvement is better than control group in attention, abstraction, memory and delayed memory iterms; according to CDR scale assessment, electropuncture group improvement is better than control group in orientation iterms.