Observation Of Brain Functional Connectivity Of Functional Magnetic Resonance In Resting Tremor Of Parkinson’s Disease

ObjectiveResearching the differential of brain functional connection between Parkinson’s disease tremor patients and healthy controls by using functional Magnetic Resonance Imaging under resting state, to explore the brain activity characteristic of Parkinson’s disease patients in resting state.MethodsSelected19Parkinson’s disease tremor patients and20healthy controls were resting state functional magnetic resonance imaging, the use of Siemens Avanto1.5T MRI system, Using the standard quadranture head coil.Head and axial magnetic resonance scan, locate cable in connection eyebrow level, three-dimensional anatomical imaging using fast Tl-weighted spoiled gradient inversion recovery(3D-SPGR) sequence parameters TR/TE=24ms/6ms, FA35°, slice thickness0.9mm, FOV=240mm×240mm, matrix=256×256; functional Magnetic Resonance Imaging scanning sequence using T2*-EPI-GRE sequence parameters:TR/TE=2000ms/30ms, FA90°, slice thickness4mm, FOV=240mmX240mm, matrix=64×64, scan time was6minutes.Data were processed using statistical parametric mapping8and Resting state fMRI data analysis toolkit and Data Processing Assistant for Resting-State fMRI and so on software pretreatment on the functional data and statistical analysis. Respectively bilateral globus pallidus as seed points, using functional connectivity method to analyze the FC differences of Parkinson’s disease patients and healthy controls.ResultsIn parkinson’s disease tremor patients, There were some brain areas of functional connectivity with right globus pallidus:Cerebellar Tonsil, left Frontal Middle Lobe, right Frontal Middle Gyrus, Precentral Gyrus, right Cingulate Gyrus. In parkinson’s disease tremor patients, There were some brain areas of functional connectivity with left globus pallidus:Inferior Frontal Gyrus, Ventral Anterior Nucleus, Inferior Frontal Gyrus, Cingulate Gyrus, right Supplementary motor area.In healthy controls, There were some brain areas of functional connectivity with right globus pallidus:right Inferior Temporal, Middle Temporal Gyrus, Nuclear, Ventral Lateral Nucleus, right SupraMarginal. In healthy controls, There were some brain areas of functional connectivity with left globus pallidus:Limbic Lobe, left Temporal Sup Gyrus, right Thalamus, Middle Frontal Gyrus, left Postcentral.In the comparison of results between parkinson’s disease tremor patients and healthy controls, There was a enhanced brain area of functional connectivity with right globus pallidus:left Frontal Middle Orbital; In the comparison of results between parkinson’s disease tremor patients and healthy controls, There were some weakened brain areas of functional connectivity with right globus pallidus:right Caudate, left Frontal Sup Gyrus. In the comparison of results between parkinson’s disease tremor patients and healthy controls, There were some weakened brain areas of functional connectivity with left globus pallidus:right Calcarine, left Insula, Parietal Inferior Lobe.ConclusionThe study found that functional connectivity of the neural activity in the brain was difference between Parkinson’s disease tremor patients and healthy controls. Default mode network and brain areas of control movement were abnormal in Parkinson’s disease tremor patients.