Evaluation Of Diastolic Heart Failure By NT-proBNP And Tissue Doppler Imaging

Objective: To explore the significance of diagnosis of diastolic heartfailure and evaluation the degree of heart failure by N-terminal pro-brainnatriuretic peptide(NT-proBNP) and mitral peak velocity of earlyfilling/early diastolic mitral annular velocity(E/Ea) with Tissue Dopplerimaging.Method:80cases of DHF patients were admitted to our departmentfrom May2013to March2014，there were42males and38females, agefrom47to93,average age71±9.Which were divided into Ⅱ、Ⅲ、Ⅳ gradeaccording to the NYHA classification, Meanwhile, another23patients inhospitalization or with normal heart function after medical examinationswere selected as the control group. They underwent conventional and tissueDoppler imaging and serum NT-proBNP level、high-sensitive C reactiveprotein and lipids were measured at the same time, and the results wereanalyzed statistically.Results: Compared with the control group, E/Ea and NT-proBNP ofDHF patients were significantly higher and statistically significant (P<0.001). With the aggravation of heart failure, concentration of NT-proBNP and E/Ea ratio were gradually increased. Significant correlations werefound between lg NT-proBNP and LVEF、E、LEVDd、LAD、E/Ea(P<0.05).The Multiple regression analysis showed lg NT-proBNP level wereindependently related to left ventricular ejection fraction and E/Ea(R2=0.323, P=0.000), and the relation to LVEF was the strongest (β=-0.440,P=0.000).Conclusion: NT-proBNP is one of the important index to diagnoseDHF，and the E/Ea in assessing the degree of heart failure was positivelycorrelated with NT-proBNP. With the NT-proBNP and E/Ea ratio by tissueDoppler echocardiography, diagnosis of DHF and evaluate left ventriculardiastolic function will be more easier and accurate.