Detection Of Coding Region Mutation In AXIN2of Xinjiang Uygur Patients With Non-syndrome Tooth Agenesis

Objective:To collect three Xinjiang Uygur non-syndromic congenital missing teeth pedigrees and six sporadic cases through clinical analysis, summarized the law of the Uighur families patients; After locating the Axin2loci screened to detect, investigate Axin2gene nucleotide changes and relevance of the disease, explore the possible pathogenesis of non-syndrome tooth agenesis.Methods:Through clinical proband find three Uygur non-syndromic hypodontia family and six sporadic cases, access to patients and their families synonymous, DNA was extracted from buccal swab samples from family members, choose exons of the Axin2gene was amplified with polymerase chain reaction technique and then directly sequenced.Result:1. The research collected cases in women significantly more than men. Lack frequency:mandibular second premolar> maxillary lateral incisor> first premolars> maxillary second premolar. Congenitally missing teeth substantially symmetrical distribution.2. The results suggest that the5nucleotide change in exon2and exon6and exonl1in Axin2gene be responsible for oligodontia in Xinjiang Uyghur.Conclusion:1. The3Uyghur pedigrees were diagnosed as autosomal dominant with incomplete significantly.2. The results suggest that5nucleotide change in Axin2gene may be responsible for oligodontia in Xinjiang Uyghur.