A Systematic Review:Probiotics Treating Minimal Hepatic Encephalopathy

Objective:The objective of the review is evaluate these randomized controlled trials that probiotics compare with conventional treatment or placebo in treat MHE were published in all world,this can find evidence that effect of probiotics for MHE.Method: First,we estabilish clear inclusion and exclusion criteria,and then use computer technology make a comprehension search in datebases,these datebases include Medline,Embase Thesis medicine,Medical TongFang and others.And,to search some documents,include conference papers and reference of the papers that have been searched. The relevant datas were extracted by two research reviewers,then they evaluate the quality and content of these papers,then check each other.disagreements are solved by two reviewers discuss.Then collate and data integration for the literatures what met the inclusion criteria. The efficacy criteria is ammonia psychological examination and incidence of clinnical hepatic encephalopathy.Result:We find12documents maybe met the inclusion criteria,six trials that including340patients met the inclusion criteria.but，jadad score show each test quality have some differences.All patients who enrolled in these trial were cirrhosis or portal hypertension and exculded che,some indicators show that probiotic have better effect than control group(p<0.05),and mhe reversal rate higher than control group(p<0.05).Conclusion:The systematic review displays that probiotics have better effect than conventional treatment and placebo in mhe’s treatment,reversal and other detection indicators.But,because the studies of mhe is few, higher quality and large sample research is more lack,so the conclusions have limitations,we must start some trials that have high quality and large sample.meanwhile,follow-up studies should be as long as possible,and strictly comply randomized,double-blind and exploration reason for lost follow-up.