Meta-analysis Of Radiofrequency Ablation Versus Hepatic Resection For Small Hepatocellular Carcinoma

Objective:To compare the effectiveness of radiofrequency ablation (RFA) and hepatic resection (HR) as an initial treatment for patients with small hepatocellular carcinoma(HCC).Methods:Clinical data of patients with small hepatocellular carcinoma underwent radiofrequenoy ablation or hepatic resection were collected from computer literature searching, which was published from2006to2011in PubMed、Wanfang and Medline etc, also performed searching based the Internet.Selecting10studies, included a total of1129patients, Meta-analysis the overall survival rate and postoperative recurrence rate by the software of Revma5.1statistical software. Publication bias was assessed by using a funnel plot.Results:1-,3-year overall survival rates had no statistically significant difference in RFA group compared with hepatic resection group(P>0.05), but hepatic resection was more effective to improve1-,3-year disease-free survival rate than RFA(P<0.05); The incidences postoperative complications of radiofrequency ablation is lower than hepatic resection significantly. Condusion:Radiofrequency ablation seems to be as effective as hepatic resection owing to comparable overall survival,and the postoperative complications rate is low,RFA can be considered as the first-line treatment of choice for small hepatocellular carcinoma.