The Prognosis Analysis Of Locally Advanced Nasopharyngeal Carcinoma Patients With Local Or Regional Residues After Intensity Modulated Conformal Radiotherapy

Objective:retrospective analysis of the Local residual patients after intensity modulated radiation therapy (IMRT):find out the influencing factors impact on the survival rate of Local middle-late nasopharyngeal carcinoma (NPC),to seek the related prognosis factors.Method and Materials:Using SPSS17.0software for135local middle-late nasopharyngeal carcinoma patients have residual after intensity modulated radiation therapy (IMRT) were selected in our hospital from August2008to January2012. The potential prognostic factors included age、gender、clinical stage、radiotherapy dose et.al. The survival differences were compared by Kaplan-Meier method, Log-rank test and Cox multivariate regression analysis.Results:(1).The2-year OS、RFS、DMFS were80%,77%.74%,the3-year OS、RFS、DMFS were72%、74%、69%;(2).Univariate analysis showed some prognostic factors including:2008T staging、2008N staging、Nasopharyngeal residue、Targeted therapy.The prescription dose of PGTVnx、D95、The residual volume of the cervical lymph nodes、The residual time;(3).Multivariate analysis identified two prognostic factors: Targeted therapy、The residual volume of the cervical lymph nodesConclusion:(1). The residual volume of neck lymph node is associated with prognosis (the patients with residual<5cc whose the5-year survival rate is higher than>5cc);(2).Chemo-radiation plus targeted therapy on survival rate is lower than chemo-radiation alone;(3).Adjuvant chemotherapy failed to improve the survival rate of patients;(4).Radiation dose has no statistical significance effect on the prognosis.