| AIM: To explore the diagnostic value of the telomerase activity inperipheral blood in hepatocellular carcinoma (HCC).METHODS: We searched those literatures of researches about therelationship between the detection of telomerase activity in peripheralblood with HCC published in recent ten years. And systematicallyevaluated both English and Chinese literatures. Meta-Disc1.4statisticalsoftware was applied to comprehensive quantitative analysis. We discussedthe overall diagnosis features of this assay by drawing characteristic.RESULTS: According to selecting and excluding standard,12independent studies were finally selected in this meta-analysis. Calculatedwith random effective model, comprehensive sensitivity was0.85(95%CI:0.82-0.87), specificity was0.84(95%CI:0.81-0.86), comprehensivediagnostic odds ratio as28.25(95%CI:17.90-44.56), average value ofmaximum intersection point of sensitivity and specificity was0.8419, Areaunder the curve was0.9098. Combined positive likelihood ratio was 5.17(95%CI:3.96-6.74), and negative likelihood ratio was0.20(95%CI:0.14-0.28).CONCLUSION: The detection of telomerase activity in peripheralblood can be used as an important index to help diagnose HCC, but morehigh-quality, large-sized and multi-center studies are still required toevaluate its clinical value. |
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