Comparison Of High-Frequency Oscillatory Ventilatio-n And Conventional Mechanical Ventilation In Neonatal Respiratory Distress Syndrome

Objective To exploration the value and safety of conventional mechanical ventilation with lung protective ventilation strategies and high-frequency mechanical ventilation in treatment neonatal respiratory distress syndrome(NRDS).Methods Eighty-six preterm infants with NRDS were enrolled in the study and randomly divided into either CMV group (n=43) or HFOV group(n=43).Blood gas values, Breathing parameters, clinical efficacy, incidence of mechanical ventilation complications were compared between two groups. Results3hours、12hours.24hours later and before ventilation taken away, the HFOV group, PaO2was obviously improved and PaCO2,OI were greater decrease than the CMV group,and the difference between the two groups was statistically significant(P <0.05).especially in24hours difference between the two groups was statistically significant (P<0.05).There were39patients survival,4died in HFOV group,and36patients survival,6died in CMV group,But there were no statistically significant between two groups(.P>0.05). Incidence of mechanical ventilation complications (Ⅲ-Ⅳ-ⅣH、 PAL、PVL) between two groups were no statistically significant between two groups(P>0.05). The duration of oxygen inhalation therapy in HFOV group was significantly shorter than that in CMV group (P<0.05). Conclusion HFOV and CMV are effective and safe mechanical ventilation method for NRDS. HFOV can improve lung oxygenation, and clinical outcome, and without increasing the risk of complications.