The Levels Of Serum UⅡ And Ghrelin Is Associated With Obstructive Sleep Apnea Hypopnea Syndrome In Type2Diabetes Mellius

[AIM] To evaluate the clinical effects and significance of serum Ghrelin andUrotensin II (UII) in obstructive sleep apnea hypopnea syndrome patients with type2diabetes mellitus (T2DM). To test the independent correlation between OSAHS andT2DM.[METHODS] All observed subjects were divided into4groups:20cases of normalcontrol subjects,20cases of simple OSAHS patients,20cases of simple T2DMpatients,20cases of OSAHS associated T2DM patients. Body height and weight,fasting blood glucose (FBG) and saturation of arterial blood oxygen (SpO2) of eachobserved subject were measured. UII and Ghrelin concentrations of serum weremeasured by the enzyme-linked immune sorbent assay (ELISA) and were comparedamong4groups.[RESULT] The levels of serum UII in the simple OSAHS patients, simple T2DMpatients, OSAHS associated T2DM patients and in the normal control subjects were（232.31±46.02）,（227.88±41.57）,（233.86±49.02） and (203.53±35.50) ng/ml,and the differences in the four groups were significant （P<0.05）. The levels of serumGhrelin in the simple OSAHS patients, simple T2DM patients, OSAHS associatedT2DM patients and in the normal control subjects were (34.99±8.02),(35.50±5.81),(36.35±5.16) and (33.91±8.28)ng/ml, and the differences in the four groups weresignificant（P<0.05）. SpO2in in the simple OSAHS patients, simple T2DM patients,OSAHS associated T2DM patients and in the normal control subjects were （76.95±9.74）,（91.00±2.57）,（73.08±8.03）and （94.3±5.6）, and the differences inthe four groups were significant （P<0.05）. The fasting blood glucose (FBG) in thesimple OSAHS patients, simple T2DM patients, OSAHS associated T2DM patientsand in the normal control subjects were (6.09±0.07),(13.44±4.34),(11.02±2.79) and(4.21±0.22)mmol/L, and the differences in the four groups were significant（P<0.05）.The BMI in the simple OSAHS patients, simple T2DM patients, OSAHS associatedT2DM patients and in the normal control subjects were (25.96±4.22),(21.48±2.97), (27.25±2.98) and (23.73±2.43) kg/m2.[CONCLUSION] The levels of serum UII and Ghrelin were all getting higher in thesimple OSAHS and simple T2DM patients, and were much more higher in theOSAHS associated T2DM patients. Increase of Ghrelin and UII may be an importantfactor for occurrence and development of OSAHS associated T2DM patients. OSAHSpatients are easy to have the T2DM. Meanwhile, T2DM addable the symptom ofOSAHS.