The Correlation Between Surgical Site Infections And Long-term Survival After RO Resection For Colorectal Cancer

ObjectiveThe aim of the study was to analyze the correlation between surgical siteinfections and long-term survival after R0resection for colorectal cancer.MethodsThis study is a retrospective analysis of1796cases of surgical treatment ofcolorectal cancer in the department of Colorectal Surgery in Fujian MedicalUniversity Union Hospital from January2000to December2013. Patients wereclassified into SSI and non-SSI groups,and we compared the disease-free survival(DFS) and overall survival (OS) at five years for the two groups.Survival datas wereperformed by SPSS19.0statistical software. Univariate and multivariate analysiswere carried out to evaluate the potential prognostic variables using the Coxproportional hazard model (α=0.05for significance).ResultsA total of1796patients underwent a curative colorectal cancer resection inthe study period.We visited1579cases and missed217cases,with lost rate12.1%.Median follow-up was53.8months.The total number of patients was98withSSI,and1481without SSI.The5year-OS and5year-DFS for those with and withoutSSI were:80.8%versus83.4%(P＞0.05) and74.4%versus79.3%(P＞0.05).Multivariate analysis showed age＞60,male,TNMstaging,pretreatment serumalbumin level,mucinous adenocarcinoma, signet-ring cell carcinoma, and rectalcancer to be independent factors associated with OS,and age＞60,male,TNMstaging,and rectal cancer with DFS.ConclusionSurgical site infection increase the length of hospital staying and delaythe time to adjuvant chemotherapy after curative resection of colorectal cancer,butnot an independent predictor of disease-free and overall survival for colorectalcancer.