Design, Synthesis And Properties Of New Functional Polyester Biomaterials

Functionalized polyester due to its controllable property, potentialbiological activity, is an important source of new generation of bioactivematerials. The synthesis is difficult seriously hampered its research andapplications. In recent years the research team created a new method foracid-induced epoxide ring-opening polymerization, provides a newpowerful tool for functional polyester synthesis. This thesis is to expandthe application of this method, the development of new functionalpolyester, and investigate its potential as a biological material.Maleic acid is a biological material can be more functional groups ofnormal metabolism in the body. Using of the new polymerization method,we prepared poly (sebacic acid diacylglycerol) maleate (PSeD-M), thebasic skeleton PSeD has been be confirmed its good biocompatibility anddegradation in our previous studies, and its side chains containing maleicacid structure, provides a wealth of sites. We conducted a systematicstudy of their properties. We find it has a relatively wide operatingtemperature, and it has a moderate mechanical properties. We use the osteoblasts to evaluate the compatibility of the cell shows and PSeD-Mhas a good biocompatibility comparable to PSeD, while better than PSeDto promote the growth of bone cells, it is possible in the boneregeneration areas have applications.Chiral Polymer is widespread in nature, these polymers have uniqueproperties, plays an important role in life. Use acid-induced of epoxyring-opening polymerization of chiral glycidol as glycerol as a precursorobtained chiral functional polyester-chiral PSeD. We test its thermalproperties and found that chiral polyesters have good crystallinity.Analysis the acid-induced PSeD epoxy ring opening polymerizationmechanism found in free radical chain growth process, the active speciesis not fixed in one molecule, but transferred in different molecules, themolecular weight of the polymer obtained is not high. So we designed anepoxy compound and a carboxylic acid group in one moleculesimultaneously, to avoid intermolecular active species in order to achievea chain transfer polymerization, to obtain a high molecular weightpolymer. We explored the synthesis of monomers.