Antidepressant Effect Of Licorice Flavonoids From Glycyrrhiza Uralensis On Stress-induced Depression Associated With Its Regulation On Critical Protein Expression Of Synaptic Plasticity In Rats

Objective: To observe the efficacy mechanism of the total flavonoids extract (Licoriceflavonoids, LF) from the Glycyrrhiza uralensis Fisch in depressive animal model.Method: The mice were randomly divided into the control group, the positive group andthree different dose groups of the total flavonoids. The antidepressant efficacy mechanism ofLF was examined by5-HTP induced head-twitching test, yohimbine induced toxicity test andreserpine test. Detected monoamine oxidase (MAO) of mice brain, explores the LFantidepressant pharmacological effects.Result: Compared with the control group, Licorice flavonoids (400,150mg·kg-1) couldobviously increase the head-twitching number induced by5-HTP (P <0.05),the Low-dosegroup (50mg·kg-1) no significant change in the number of mice compared shakes saline group（P>0.05）; Yohimbine-induced mortality of mice was not statistically significant（P>0.05）;markedly improved such symptoms as eye ptosis and akinesia of mice (P <0.01)induced by reserpine. However, there is no difference between the control group and thetreatment group in the mortality induced by reserpine hypothermia. And it had no effect onmice brain hippocampus, cortex, hypothalamus tissues monoamine oxidase activity also hadno effect（P>0.05）.Conclusion: Licorice total flavonoids of depression in mice with obvious antagonism,and its mechanism may be related to enhanced5-serotonin nerve function related to, but notthrough increased monoamine oxidase activity increased5-HT neurotransmitter。...