Model-based Stimulation Analysis On Epiretinal Electrical Stimulation Of Different There Dimentional Electrodes

Epiretinal prosthesis has achieved great success in helping restorevision for the blind patients of retinal degenerative diseases. Stimulatingelectrodes play a crucial role in performance of epiretinal prosthesis. Thisstudy investigated the effects of different three-dimensional electrodes onepiretinal stimulation by computational modeling analysis. Differentthree-dimensional models of disk and non-planar electrodes were used inthe epiretinal electrical stimulation. Multi retinal ganglion cells (RGCs)were modeled to study the responses of RGCs under electrical stimulationby different-type electrodes. Small-size electrode located near the retina ismore efficacious to activate RGCs with the low threshold current as long asits charge density is with the safe limit. Non-planar electrodes couldprovoke different activation responses of RGCs compared with diskelectrodes. Concave electrodes performed superior stimulation selectivityand electrode safety, while convex electrodes showed weak stimulationselectivity and electrode safety. Investigation on effects of different3-Delectrodes may be beneficial to optimization of electrode design andimprovement in performance of epiretinal prosthesis.