The Application Of ASL In Assessing Ischemic Cerebrovascular Disease

The First PartTheApplication ofASLinAssessing Cerebral Blood Flowin Healthy VolunteersObjective To evaluate the correlation between cerebral blood flow(CBF) with age andgender with arterial spin labeling magnetic resonance imaging.Methods Forty healthy volunteers, who were divided into four groups (A, B, C and D)according to age, underwent conventional MRI and ASL(Q2TIPS) examination.Cerebral blood flow (CBF) maps were obtained and reviewed. ROIs were respectivelyselected in bilateral cerebral hemispheres and CBF values were generated. Thecomparison of CBF value between the left and right hemispheres and within the fourage group differences were performed. The relationships between CBF value with ageand gender were also analyzed.Results There was no statistical differences of CBF in white or gray matter betweenbilateral hemispheres in all groups (P>0.05). Asignificant positive correlation was found between age and the CBF values of the left whole brain (r=0.378, P=0.020) ingroup C, while no significant difference of CBF in bilateral gray matter, white matteror whole brain was detected among all age groups (P>0.05). There was no statisticaldifference of CBF between male and female volunteers (P>0.05).Conclusion The study confirms the value of ASL technology in clinical application.The preliminary results suggest that cerebral blood flow values do not significantlyassociated with age or gender. TheApplication ofASLinAssessing IschemicCerebrovascular DiseaseObjective To evaluate the research value of arterial spin labeling in ischemiccerebrovascular disease.Methods We selected35patients with ischemic cerebrovascular disease.25cases ofthese patients were clinical diagnosed of acute cerebral infarction (6-72hours), while10cases of clinical diagnosis of transient ischemic attack(TIA).All these patientsunderwent conventional MRI, MRA and ASL sequence examination,5patients oflarge area acute cerebral infarction with dynamic susceptibility contrast enhancementexamination.Cerebral blood flow (CBF) maps and DSC-PWI maps were obtained andreviewed.Comparing and analyzing the functional magnetic resonance imaging in thediagnosis of ischemic cerebrovascular disease, highlight the advantages of ASL in thediagnosis of ischemic cerebrovascular disease.Results10cases of large area acute cerebral infarction, the positive rates of DWIwere100%, ASL-CBF maps shows the corresponding region of the low perfusionarea;15cases of small area acute cerebral infarction, the positive rates of DWI were100%, while ASL-CBF maps shows73.3%with the region of the low perfusionarea.MRAshows the blood supply of vascular occlusion or different degrees of stenosis.10patients of TIA were negative for DWI, while8patients of ASL-CBFmaps showing different degrees of perfusion defects.MRA display the blood supply ofdifferent degrees of arteriosclerosis and stenosis.Conclusion As a non invasive perfusion imaging methods, ASL has obviousadvantages in diagnosing ischemic cerebrovascular disease,and is expected to replacethe invasive examination technology in the cerebral blood flow perfusion imaging。...