Study On The Correlation Factors Of Hyperuricemia And The Effect Of Apolipoprotein E Gene Polymorphism

Objective Analysis of prevalence and influence factors of hyperuricemia on physicalexamination population, apolipoprotein E gene rs429358and rs7412polymorphisms (SNPs),determine the apolipoprotein E gene genotype and allele distribution in the back to the Hannationality and the case group and the control group, relation between ethnic differenceanalysis and hyperuricemia apolipoprotein E gene, and provide the basis for the molecularmechanism of hyperuricemia, and provide scientific basis for prevention and treatment ofhyperuricemia.Methods1) collected from2013a medical unit physical examination population ingeneral,anthropometric and biochemical indexes information;2) survey with self-designedquestionnaires were generally, family history, history of disease and treatment of persons;using1:1matched case-control study method on July,2013-2013year in November in amedical institutions for regular health examination population,according to the inclusion andexclusion criteria, identify450unrelated hyperuricemia patients as case group, including362cases of male, female88cases,353cases and97cases of Han, Hui, mean age (49.31±10.24)years old;matching according to age, gender and ethnicity, selection450healthy unrelatedfrom health examination during the same period of the crowd as the control group, including362cases of male, female88cases,353cases and97cases of Han, Hui, mean age (50.78±10.20) years old; extraction research object fasting blood5ml, detected by detection of enzyme reaction apolipoprotein E gene rs429358and rs7412polymorphism.Results1) the blood uric acid level of male is higher than female, serum uric acid level in60~years old group controls the highest, four organs of the blood uric acid level examinationare the highest, and the difference is statistically significant;2) in the physical examinationpopulation prevalence rate was25%, the prevalence rate of male (29.5%) than women(14.1%), female from the age of40with the increase of age the prevalence of hyperuricemiaincreases, greater than or equal to70year old age group had the highest prevalence ofhyperuricemia; male with age increasing prevalence of hyperuricemia was reduced below40years of age, the highest prevalence rate of high uric acid levels, the differences werestatistically significant;3) male, female volunteers, hypertension, hyperlipidemia examinationthan sick persons blood uric acid level is high, the male diabetic subjects than in subjects withhigh serum uric acid levels, while women are just the opposite, with BMI increasing level ofmale, female subjects serum uric acid levels are on the rise, blood uric acid level the serumcreatinine level exceeds the normal level of male, female subjects than normal level ofexamination of blood uric acid level is high, and the difference was statistically significant;4)due to Result shows,creatinine, hyperlipidemia, hypertension, BMI, gender, occupation, ageand diabetes in the public security organs are factors of hyperuricemia effect;5)comparedwith the case group and control group, blood glucose, total cholesterol, triglyceride, lowdensity lipoprotein cholesterol, systolic pressure,diastolic pressure, serum creatinine and BMIlevels higher than that of the control group, while high density lipoprotein group was higherthan the case group, the difference had statistical significance;6) the multiple linearregression analysis showed that gender, creatinine, triglyceride and factors that influence thecase group and blood uric acid, creatinine, triglyceride, gender and BMI are the factorsinfluencing the control group blood uric acid;7) Apo E gene the genotype and allelefrequencies were no statistically significant differences in the distribution of case group andcontrol group, male and female, Hui and Han nationality);8cases in group Apo of different E genotypes in serum uric acid, triglyceride,systolic blood pressure and serum creatinine level isdifferent, the difference has statistical significance. Two two comparison of results, serum uricacid index,content of genotype E2/3was higher than that of E3/4, content of genotypeE3/4was higher than that of E3/3, content of genotype E2/4was higher than that of E3/4;triglyceride index, content of genotype E3/4was higher than that of E3/3;index of systolicblood pressure, the E4/4genotype was significantly higher than those of E2/2, E2/3, E2/4,E3/4and E3/3, genotype E2/3was higher than that of E3/3; creatinine index, content ofgenotype E2/4was higher than that of E4/4,E3/3, E2/3, E3/4and E2/2, there was significantdifference.Conclusion1) the study population the prevalence of hyperuricemia is higher, and theincidence rate in male is significantly higher than women;2) the relationship betweenhyperuricemia and hyperlipidemia, impaired renal function, obesity,hypertension, diabetesclose;3) still can not think of hyperuricemia associated with apolipoprotein E genepolymorphism.