The Expression And Clinical Significance Of PDCD5,eIF4E And INOS In Sinonasal Squamous Cellcarcinoma

Background and ObjectiveSinonasal squamous cell carcinoma is the third largest head and neck cancer following nasopharynx cancer and laryngocarcinoma,because its early symptom is not obvious, no specificity, and be close with the surrounding tissues and organs, complications and destructive wound be more at last, so more doctors and professor has regarded it as the key research object.NSCC etiology and pathogenesis is complex, may be related to chronic inflammation, tumor progression, low immune function and be exposed to radiation and so on, still not clear, so in order to improve the diagnosis and cure rate we shound to understand the pathogenesis at first.Programmed cell death 5 can promote lots of tumor cell apoptosis and inhibiting tumor cell proliferation,it plays an important regulater role in the process of cell apoptosis.Eukaryotic translation initiation factor 4 e is the most effective regulating factor at m RNA translation stage.At normally,the effect fo e IF4 E is maintain normal life activities needs translation m RNA, but when a glut of its expression can promote various coding carcinoma protein and promoting factor m RNA expression.Inducible nitric oxide synthase play its physiology and pathology function mainly through to stimulate the NO formming.At pathological, i NOS wound be active by certain cytokines, caused the rapid increase of NO,play a role in the tumor’s occurrence, development and metastasis.This research through analysis immunohistochemical staining of PDCD5, e IF4 E and i NOS protein expression and distribution in NSCC, discuss them role of occurrence, development and transfer mechanism in NSCC so as to the etiology, pathogenesis of NSCC, provides some references for the clinical diagnosis and treatment. Materials and MethodsThis study was performed selected intact nasal surgery, clinical data archive wax blocks from the first affiliated hospital of zhengzhou university at 2011 to 2014, including cases of NSCC 55 cases, SNIP 28 cases, normal inferior turbinate mucosa 15 cases,detection the expression of protein PDCD5, e IF4 E and i NOS by immunohistochemical staining. Results1. PDCD5 is highly expressed in normal inferior turbinate mucosa, expressed in NSCC group rate is the lowest, comparison between groups was statistically difference, prompt PDCD5 related to the occurrence of a squamous carcinoma;In comparison of NSCC clinical expression differences between table visible PDCD5 expression has nothing to do with age and is associated with lymph node metastasis, is associated with tumor grade and tumor stage, the higher the pathologic stage, expression is higher, the higher the clinical stage, the less expression.2. EIF4 E expression is lower than in the control group "and NSCC group, in the group of" the expression below NSCC, comparison between groups was statistically difference.EIF4 E between different clinical evidence in NSCC expression is also statistically significant, the lower the degree of differentiation e IF4 E expression of the stronger, the higher the tumor staging e IF4 E expression.3. The expression of i NOS in the control group was lower than that in group "and NSCC, in" the expression of below NSCC group, each group to compare the difference was statistically significant.The expression of i NOS between different clinical indicators in NSCC there are statistically significant, the lower case classification i NOS expression is higher, the higher the clinical stage of i NOS expression is higher,and has nothing to do with age.4. By Spearman’s correlation test, the e IF4 E and PDCD5 expression in NSCC is negatively correlated(P < 0.05); PDCD5 and i NOS expression in NSCC is negative correlation(P < 0.05);EIF4E and i NOS expression in NSCC is positively correlated(P < 0.05) Conclusions1. The inhibition of PDCD5 may promote the occurrence of NSCC, e IF4 E and high expression of i NOS may promote the occurrence of NSCC.2. The inhibition of PDCD5 may promote the development of NSCC, e IF4 E and high expression of i NOS may promote the development of tumor and metastasis.3. EIF4 E and i NOS during the onset of NSCC has synergy, the two interact can promote the development of tumor.4. PDCD5 and two other factors in the process of NSCC antagonism.