Analysis Of The Application Of Local Anesthesia In Laparoscopic Cholecystectomy

Objective:to evaluate the application of local anesthesia in laparoscopic cholecystectomy (LC), Providing a reference for clinical use.Methods:using Cochrane analysis method by collecting randomized controlled trials (RCTs) refer to local anethesia(LA) from both chinese and english electronic database. Using the Jadad score for quality assessment, Review manager 5.2 software for Meta-analysis.Results:A total of 59 RCTs as 3730 patients, including 1888 in LA group and 1842 in control group were accepted. The combined analysis (Meta analysis) results suggested there was statistical significant difference between the local anesthesia group and control group in postoperative pain (Visual Analogue Scale/Score, VAS). There was statistically significant difference between both preoperative and postoperative use of local anesthesia groups and control group in VAS. Further analysis showed that, there was no statistically significant difference between using local anesthesia preoperative and postoperative in VAS; There was statistically significant difference between both local infiltration anesthesia with incisional-wound and various methods using intraperitoneal of local anesthesia and the control group in VAS; There was statistically significant difference between either ropivacaine, bupivacaine, levobupivacaine and the control group in VAS while there is no statistically significant difference between the lidocaine and control groups in VAS.Conclusion:the effect of local anesthesia is obvious regardless of timing or position; You may use either ropivacaine, bupivacaine or levobupivacaine while the effect of lidocaine seems not ideal.