Comparison Of Single-Agent Chemotherapy Treatment Of Gestational Trophoblastic Neoplasia With Combination-Agent And The Analysis Of Factors For Developing Drug Resistance

Objective:To compare of single-agent chemotherapy treatment of gestational trophoplastic neoplasia with combination-agent and the analysis of factors for developing drug resistance.Materials and methods:This paper collected the hospital between January 1999 and October 1999, guang xi medical university medical school affiliated tumor hospital.Diagnosed with low risk and gestational trophoblastic tumor treatment for the first time the clinical data of 85 cases of patients. Summarized retrospectively the clinical data, to completely relieve the required number of course, the incidence of drug resistance and related factors and related adverse reaction of chemotherapy.Conclusion:Single drug group and MDT group in remission rate, ni, and there was no statistically significant difference on the adverse event the risk of drug resistance in patients with stage Ⅱ-Ⅲ.Background:Gestational trophoblastic neoplasia refers to the embryo of sertoli cell tumor malignant lesions and form tumors. Since the advent of effective chemotherapy drugs, low-risk GTN cure rate was 100%, and the high risk of GTN cure rate was 86%. Today for low-risk GTN chemotherapy, there are many different solutions, but so far did not gain a strong evidence to show that a certain kind of chemotherapy regimens better curative effect and higher safety.Objective:System evaluation low-risk GTN first applied different first-line chemotherapy regimens of chemotherapy treatment effect and drug adverse reaction.Materials and Methods:1.Search strategy:The main retrieval methods for network retrieval. System retrieval Pubmed, CBM, Science Direct, China Science and technology journals (CINK), Medline database and related references. Manual retrieval relevant references, academic report, meeting minutes, etc.2.Selection criteria:collect all initial chemotherapy low-risk GTN relevant randomised controlled trials and controlled clinical trials.Limited to Chinese and English languages, limited to retrieval time between January 2000 and January 2000.3. Data collection and analysis:By the author to extract the relevant data and independent and quality assessment. Using RevMan5.2 Meta analysis software.4. The main outcome assessment:(1) Efficacy of initial chemotherapy complete response rate, initial chemotherapy failure rate (including the incidence of ni and due to the change of adverse reaction of chemotherapy scheme), resistance and the recurrence rate.(2) Safety indicators:the incidence of adverse reaction of chemotherapy.Conclusion:Bi-ACT, vp-16,5-ACT scheme has good curative effect; Contrast in the incidence of adverse reaction:MACT and MTX-FA have a higher incidence of adverse reaction; Contrast drug resistance in MTX-FA prone to drug resistance; Compared to initial chemotherapy failure rate:MTX (has nothing to do with the different method) for the first time chemotherapy failure rate is high; Chemotherapy regimens for drug adverse reaction needs to be changed:5 d-the incidence of MTX more; This study included in the Meta analysis research methodological quality is higher, so as to improve the reliability of the above conclusion, but due to the Meta analysis can not replace the high quality, large sample randomized controlled studies, this conclusion has yet to be confirmed that high quality research in the future.