Fulminant Type 1 Diabetes Clinical Characteristics Analysis In China

Objective Toinvestigatethe clinical features of fulminanttype 1 diabetes(F1D).Methods Retrospective analysis patients with ketosis or ketoacidosis in 9 guangxi medical university affiliated hospital from January 2003 and December 2014.According to the diagnosis standard of fulminant type 1 diabetes was putted forwardby Hanafusa, there are 7 FID patients.The clinical features of 7 FID patients were analyzed.At the same time, inputting keywords "fulminant type 1 diabetes" refer to about the document of F1D in China from 2005 to 2014 through the use ofHow Net, ten thousand party, VIP Chinese database system. Repeat, reviews, meetings, and only abstract has been removed, there are remaining 111 literature. Adoptting diagnosis standard of fulminant type 1 diabetes was proposed by Hanafusa,45 F1D patients from 111 literature and7 F1D patients from 9 guangxi medical university affiliated hospital were intaked.The clinical features of 52 F1D patients were analyzed, and compared with the clinical data of F1D patients of Japan and South Korea.Results:1、Among 7 cases of fulminant type 1 diabetes patients in our hospital,5 cases were the men,2 cases were women. They are the onset with ketoacidosis,and duration from the onset of hyperglycemic symptom to ketoacidosis was 1 to3 days, and the onset of blood sugar were greater than 16.0 mmol/L, their islet function were poor, fasting serum C-peptide level<0.10 nmol/L (<0.3 ng/mL) and <0.17 nmol/L (<0.5 ng/mL) afterintravenous glucagon (or after meal) load at onset.All patients of the onset have the electrolyte metabolic disorders and renal failure some patients also appeared abnormal liver enzymes, muscle enzyme and amylase enzymewere They were all improved after treatment, all the F1D patients used insulin to control blood sugar after discharge. Dailyaverageinsulindosewere16-49IU.2、① The average age of FID patients was 32.2+12.6 yearsin China, more than 18 years old accounted for about 96% of the total number of patients,And the most patients were 18 to 30 years, accounted for about 52% of the total.②No difference in onset years old, blood glucose, course of diseases, HbAlc level, arterial blood pH, serum sodium, serumpotassium betweenmale patients with fulminant type 1 diabetes and female patients with fulminant type 1 diabetes. Serumpotassium of male patients with fulminant type 1 diabetes were higher than female patients with fulminant type 1 diabetes.③No difference in onset blood glucose, course of diseases, HbAlc level, arterial blood pH, serum sodium, serumpotassium betweencorrelation pregnancy patients with fulminant type 1 diabetes and not pregnancypatients associated with fulminant type 1 diabetes.④Comparedwith Japanese patients, Chinese FID patients hadyounger age, shorter duration,lowwer blood sugar,higher serum potassium,lowwer serum sodium.⑤Compared with South Korea, Chinese F1D patients had younger age, higher serum potassium.Conclusion:① Fulminant type 1 diabetes is not rare in our country, thepatientsaremainlyadults.② Clinical features of PF patients are similar with those of NPF patients. ③Compared with Japanese and South Korea, Chinese F1D patients had younger age, higher serumpotassium.