The Analysis Of Carbohydrate And Lipid Metabolism In Pregnant Women With Thyrodid Dysfunction And Its Effect On Maternal And Infant Prognosis

Objectives:This study aims to explore the metabolism of blood lipids and blood glucose metabolism of pregnant women who have gestational thyroid dysfunction in early pregnancy and late pregnancy by detecting their fasting plasma glucose (GLU), triglyceride (TG), low density cholesterol (LDL-C) and total cholesterol (TC) levels to analyze their complication.Method:From October 2013 to October 2013, data of pregnant women with hyperthyroidism, hypothyroidism, subclinical hypothyroidism and hypothyroxinemia and data of normal pregnant women were collected from the First Affiliated Hospital of Guangxi Medical University. The levels of fasting plasma glucose (GLU),triglyceride (TG), low density cholesterol (LDL-C), high density cholesterol (HDL-C) and total cholesterol (TC) in early pregnancy and late trimester of pregnancy were then compared.Result:Pregnant women with hyperthyroidism have a higher level of TG, HDL-C and TC than normal pregnant women but have a lower level of TG, HDL-C and TC than normal pregnant women. Contrarily, the results for pregnant women with hypothyroidism is opposite. With the progress of pregnancy, the levels of TC and TG gradually rise and is statistically significant(P<0.05). The levels of TG、HDL-C and TC of the pregnant women with hypothyroidism and subclinical hypothyroidism decrease significantly but their GLU level difference during pregnancy is not statistical significance。In pregnant women with hypothyroidism, the incidence of GDM is highest, they have higher levels of TC、TG and GLU than the other groups.Conclusions:Pregnant women who have gestational thyroid dysfunction are more likely to have glucose and lipid metabolism disorders. The levels of TG, HDL-C and TC in pregnant women with clinical hypothyroidism and subclinical hypothyroidism decreased significantly during pregnancy. Women with controlled hyperthyroidism have a lower incidence of postpartum hemorrhage and pregnancy-induced hypertension. Pregnant women with controlled hypothyroidism have a relatively low risk of GDM, gestational hypertension and postpartum hemorrhage. Pregnant women with abnormal thyroid function during pregnancy have a higher rate of GDM than normal pregnant women. Pregnant women with hypothyroidism have lower incidence of low birth weight newborns but a higher incidence of neonatal asphyxia. Pregnant women with thyroid dysfunction are more prone to glucose and lipid metabolism disorder, therefore, we need to focus on monitoring.