| Background:the risk factors for coronary heart disease research, has been clear mainly include age, male, smoking, and obesity, high blood pressure, diabetes and hyperlipidemia and other traditional risk factors, but there are still some patients with coronary heart disease(CHD) none of these traditional risk factors exist, therefore the domestic and foreign researchers are looking for a new can predict the degree of pathological changes of coronary artery disease risk factors, including apo AI/apo B ratio, bilirubin, serum homocysteine were studied, and draw the conclusion of prediction in coronary heart disease(CHD). But the results are consistent in different areas of the? Is likely to coronary heart disease(CHD) in different areas of the crowd of risk factors for conclusions are different. Abstract: bjective: By observing the patients with coronary heart disease(CHD) in sichuan area of apo AI/apo B ratio and serum bilirubin, to explore the serum homocysteine apo AI/apo B ratio, bilirubin, homocysteine and coronary heart disease(CHD) in patients with coronary artery lesion degree of correlation. Methods : Collect our hospital(people’s hospital in sichuan province) from June 2014 to March 2015 in the hospital 500 cases had clear the atherosclerotic process in the diagnosis of coronary heart disease(CHD) in coronary heart disease in patients with clinical medical records, the information including the patient’s general condition: age, hospital number, gender, drinking, smoking, always with and without history of hypertension and diabetes. Blood biochemical results include: blood total bilirubin and indirect bilirubin, direct bilirubin, serum apo AI, apo B, apo AI/apo B ratio, homocysteine and the result of coronary angiography. Selected patients were performed coronary angiography examination, according to the results of coronary artery lesion counts, it is divided into three groups: single lesion, the double branch lesion group and group three pathological changes, according to the Gensini score calculation of coronary artery stenosis in patients with coronary artery lesions points, according to the result of the integral can be divided into three groups: mild lesions, the moderate group and severe lesion group(0 < Gensini score 12 or less for the mild group, 12 < Gensini score < 32 for moderate group, the Gensini score 32 for severe group) or higher. At the same time will be different coronary artery lesion count of three groups, the different degree of coronary artery lesions of three groups of serum apo AI, apo B, apo AI/apo B ratio, total bilirubin and indirect bilirubin, direct bilirubin and homocysteine comparative analysis. Further by Spearman correlation analysis of coronary artery lesion counts, the degree of coronary artery stenosis and serum apo AI, apo B, apo AI/apo B ratio, total bilirubin, indirect bilirubin, direct bilirubin, and analyzed the correlation between homocysteine. And then USES the unconditioned multiariable Logistic regression analysis method for screening of coronary heart disease(CHD) independent risk factors for coronary artery lesion severity. Results: This study selected patients in sichuan area o with coronary heart disease(CHD) in coronary artery lesion count points compared in three groups of age and the number of cases with diabetes mellitus was statistically significant(P < 0. 05), namely the coronary disease lesion count, the more the patient’s age, and at the same time and the higher the proportion of diabetes mellitus; serum apo AI, apo B levels of three groups of patients, indirect bilirubin, apo AI/apo B ratio comparison were statistically significant(all P < 0.05); and the three groups of patients of total bilirubin, direct bilirubin, after compare homocysteine had no statistical difference(P > 0.05); double branch serum apo AI lesion group were significantly lower than that of single lesion group(all P < 0.05), serum apo B levels three lesion group and indirect bilirubin were significantly higher than that of single lesion group(all P < 0.05), three lesion group, serum levels of apo AI apo AI ratio/apo B were significantly lower than that of single lesion group(all P < 0.05); the single lesion group and double branch lesion group, serum levels of apo B apo AI/apo B ratio, indirect bilirubin is no statistical difference(P > 0.05), double branch lesion group and three pathological changes of serum levels of apo AI, apo B levels, apo AI/apo B ratio, indirect bilirubin is no statistical difference(P > 0.05). Calculate according to the Gensini score system in patients with coronary heart disease, coronary stenosis, integral is divided into three groups according to the coronary artery pathological changes, comparison between the three groups of coronary artery lesion severity men smoke and the number of cases was statistically significant(P < 0. 05), namely the more serious the degree of coronary artery lesions of the patients, the number of male proportion and the number of smokers is higher; the apo AI serum levels of three groups of patients, apo AI/apo B ratio, total bilirubin, direct bilirubin, homocysteine comparison were statistically significant(P < 0.05), while serum apo B, indirect bilirubin of three groups of patients is no statistical differences(all P > 0.05); severe lesion group, serum levels of apo AI apo AI/apo B ratio was significantly lower than that of mild and moderate lesion group(all P < 0.05), while severe lesion group of total bilirubin, direct bilirubin, homocysteine were significantly higher than mild lesion group and moderate lesion group(all P < 0.05); Serum apo AI, apo B and apo AI/apo B ratio, total bilirubin and indirect bilirubin, direct bilirubin, homocysteine and extent of coronary artery stenosis and coronary artery lesion count after the Spearman correlation analysis to the correlation of the results of the analysis showed that serum level of apo AI and apo AI/apo B ratio and degree of coronary artery stenosis and coronary artery lesion count were significantly negative correlation(P < 0.05), homocysteine and degree of coronary artery stenosis and coronary artery lesion count was significantly positive correlation(P < 0.05), serum apo B levels, total bilirubin and indirect bilirubin, direct bilirubin and degree of coronary artery stenosis and coronary artery lesion count no correlation(P > 0.05). Last line multiariable Logistic regression analysis showed that age, homocysteine, apo AI/apo B ratio are the influence factors of coronary artery lesion severity, including age, homocysteine and positively associated with the degree of coronary artery lesions(P < 0.05). Apo AI/apo B ratio and the degree of the coronary artery lesions, negative correlation(P < 0.05). Conclusion: Apo AI/apo B ratio, homocysteine and coronary heart disease patients of coronary artery lesions in sichuan area closely related to count and degree of coronary artery lesions, is a risk factor for coronary artery lesion severity, compared with homocysteine, apo AI/apo B ratio of coronary artery lesion severity more effective risk assessment can be used for clinical predict the extent of coronary artery lesions stenosis in patients with coronary heart disease(CHD). Serum bilirubin and coronary heart disease patients of coronary artery lesions in sichuan area count and no significant correlation between degree of coronary artery lesions. |
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