Single-center Clinical Study Of Kawasaki Disease And Coronary Artery Lesions

Objective To analyze the clinical characteristics of Kawasaki disease (KD),explore the KD patients with risk factors for coronary artery lesions(CAL),and study the recovery or re-occurs of CAL in children with KD during follow-up.Methods A retrospective analysis of 204 cases of children with KD clinical history and post follow-up data.We analyzed the clinical features of the center KD children,compared the difference between CAL group and NCAL group,observed the recovery of CAL during follow-up.Results (1)204 cases of children with KD, male to female ratio was 3.0:1,≤3 years of age accounted for 79.41%,<5 years of age accounted for 95.09%,54 cases were complicated by CAL, the rate was 26.47%.(2)The incidence of the disease in all seasons, spring, summer festival of more diseased population.(3)CAL group and the group of children with average NCAL fever, self-heating to the start time of IVIG therapy, IVIG dose, and white blood cell (WBC), platelets (PLT), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), red blood cell (RBC) the difference was statistically significant (P<0.05).(4)Most children with KD better prognosis, a few patients during follow-up without stopping, failure to doctor referral, took place in the latter part of CAL.Conclusions l.KD occurred in 5 years old boy, CAL incidence declining trend, seasonal distribution is different, the onset of spring and summer high numbers.2.Thermal process is longer, does not regulate the use of IVIG in children with a higher incidence of KD CAL.3.WBC, PLT, ESR, CRP increased KD RBC children should be alert to the concurrent decrease in the risk of CAL, the KD treatment and prognosis of some reference value.4.Referral law, prescribed medication in favor of CAL recovery, avoid late coronary artery disease.