| Objective1.To evaluate the curative effect of Electroacupuncture on the patients with menopause related symptoms during the menopausal transition period, the preliminary except the placebo effect;2.Electroacupuncture treatment of menopausal symptoms during the menopausal transition period related to the safety and acceptability of.MethodsWill meet the inclusion criteria of 30 patients were randomly divided into experimental group and control group, each group of 15 people. The two group of electroacupuncture were density wave, frequency of 10/50 Hz, current intensity is0.5~1.0 m A. Two groups were treated for 8 weeks, 3 times a week, 30 minutes each time the needle for treatment of patients, evaluation before treatment and 20 weeks after4 weeks, 8 weeks later, and 32 weeks after the post menopausal symptoms assessment scale score(MRS), quality of life of peri menopausal period(MENQOL) were evaluated,and compared within groups,between group.Results1.Comparison of the clinical efficacy:The test group for 8 weeks the effective rate was 92.9%,control group 8 week treatment efficiency was 13.3%, the experimental group 8 weeks total efficiency and control group had significant difference compared, with statistical significance(P<0.01); thus, total effective rate of the experimental group was significantly better than the control group.2.MRS scale effect evaluation:Compared with the baseline, 4 weeks after the test group MRS score decreased value of 5.93±2.27, control group MRS score reduction value of 2.33±3.717, compared with differences between groups(P<0.01); 8 weeks after the test group MRS score decreased value of 10.79±3.24, control group MRS score reduction value of 2.53±5.51, compared with the group differences room(P<0.01), that during the treatment period, the experimental group improved menopausal symptomsassociated with significantly better than the control group. The difference of the total score of experiment group after 4 weeks of treatment before and after self(P<0.01), the control group total score comparison of difference(P<0. 05), after 8 weeks of treatment,the test group was statistically significant(P<0.01), before and after the comparison of their total score comparison control group no difference(P>0.05), the test group 8weeks and 4 weeks after the comparison within group have significant difference(P<0.01); the control group after 8 weeks compared with 4 weeks after the group had no statistical significance(P>0.05); that the test group can effectively alleviate the symptoms associated with menopause transition, and treatment time is longer the more significant effect, the effect is indeed the treatment effect. The control group in the treatment for 4 weeks, but in 8 weeks after treatment had no effect, that comfort control group were reflected in the early treatment, consider the disease itself and the characteristics of the patients with psychological hint.Compared with the baseline, 20 weeks after the test group MRS score decreased value of 10±5.038, control group MRS score reduction value of 2.73±6.39, compared with differences between groups(P<0.01); 32 weeks after the test group MRS score decreased value of 8.36±4.72, control group MRS score reduction value of 2.87±4.49,compared with the group differences room(P<0.01), described in the follow-up period,test group to improve the efficacy of menopause related symptoms significantly better than the control group. Compared with the treatment after 8 weeks, 20 weeks after the test group MAS score decreased value of-0.79±3.53, intra group comparisons differences(P<0.01), control group MRS score reduction value of 0.20±4.95, group has no difference(P>0.05); after 32 weeks the experimental group the MAS score decreased value of-2.43±3.18, within group comparison no difference in control group(P>0.05), MRS score decreased value of 0.33±3.42, group has no difference(P>0.05).Description of experimental group after treatment effect has been maintained until the follow-up period of 20 weeks, 32 weeks after a downward trend, considering the aging process and the disease itself; the control group during the follow-up period without anyeffect.3.Quality of life of peri menopausal period evaluation: compared with the baseline, 4weeks after the test group MENQOL score decreased value of 20.43±10.82, control group MENQOL score reduction value of 7.47±17.35, the difference was statistically significant between the two groups(P<0.01); 8 weeks after the test group MENQOL score decreased value of 37.07±15.97, control group to reduce the value of MENQOL score 7.73±18.01, the difference was statistically significant between the two groups(P<0.01), that during the treatment period, the experimental group improved significantly better than the quality of life of patients in the control group during the menopausal transition period. The difference of the total score of test group 4 weeks after the treatment itself(P<0.01), the control group before and after a total score comparison of no difference(P>0.05), after 8 weeks of treatment, the test group was statistically significant(P<0.01), before and after the comparison of their total score comparison control group no difference(P >0.05), the test group 8 weeks and 4 weeks after the comparison within group have significant difference(P<0.01); the control group after 8 weeks compared with 4 weeks after the group had no statistical significance(P>0. 05); that the test group both in the treatment of 4 weeks or 8 weeks in improving the quality of life have a significant effect, and with the duration, efficacy test group was more obvious. The control group both in the treatment of 4 weeks or 8weeks without effect.Compared with the baseline, 20 weeks after the test group MENQOL score decreased value of 10±5.04, control group MENQOL score reduction value of 2.73±6.39,compared with differences between groups(P<0.01); 32 weeks after the test group MENQOL score decreased value of 8.357±4.717, control group MENQOL score reduction value of 2.867±4.486, compared with the group differences room(P<0.01),described in the follow-up period, test group to improve the efficacy of menopause related symptoms significantly better than the control group. Compared with the treatment after 8 weeks, 20 weeks after the test group MENQOL score decreased valueof-3.79±13, group has no difference(P>0.05), 20 weeks control group MENQOL score reduction value of 2.33±13.92, intra group comparisons differences(P>0.05), 32 weeks after the test group MENQOL score decreased value of-4.00±9.8, within group comparisons of no difference(P>0.05); control group 32 weeks after MENQOL score reduction value of 1.73±14.67; comparison within group differences(P>0.05). That electroacupuncture therapy after effect continued until the follow-up period of 32 weeks,had not been weakened because of the extension of time; the control group in improving the quality of life of the patients was without any effect.4.Comparison of MAS menopausal symptoms improvement: In the experimental group after 4 weeks of treatment can improve the hectic fever and sweating, heart discomfort, depression, anxiety, fatigue, joint pain, of symptoms(P<0.05), after 8 weeks is also continuous improvement(P<0.01); the experimental group only problems,vaginal dryness, bladder problems with sleep in 8 weeks after treatment to get improved(P<0.05); control group can only improve the hectic fever and sweating symptoms(P<0.05), embodied in the 4 week after the treatment, the rest of the symptoms have not improved; after 8 weeks of treatment, the experimental group score lower than the control group in the depression, irritability, easy fatigue, problems, vaginal dryness,bladder problems, joint pain etc. symptoms(P<0.05), cardiac symptoms were significantly different compared with that in 4 weeks, 8 weeks after treatment between the two groups(P<0.05), both for 4 weeks or 8 weeks, in the heart of discomfort symptoms scores of test group than in the control group(P<0.05).5.Electro acupuncture safety and Sustainability:For a total of 30 patients in the acupuncture treatment process, only 1 cases of adverse reactions and quit after acupuncture treatment, the rest were no recent and long-term discomfort, good safety that electroacupuncture therapy. In the EA discomfort, patients received evaluation: the experimental group patients discomfort score was 1.68 ±1.31, 0 in control group,compared with the difference between the two groups(P<0.01); the experimental group received a score of 3.14±0.79, the control group is 3.67±0.45, two groups has statisticalsignificance(P<0.05), that in the test group had mild discomfort reaction, consider acupuncture induction, does not affect the treatment, and the experiment group received a mean score more than 3 points, proved that electroacupuncture as a treatment, easy to be accepted by patients.Conclusion1.Electro acupuncture therapy can significantly improve the menopausal transition menopause related symptoms, its efficacy is indeed the treatment effect, and the effect lasted until the follow-up period of 20 weeks, there is a downward trend in 32 weeks;false electroacupuncture in the treatment of 4 weeks after a certain comfort, but did not have any role in the 8 weeks after the treatment and follow-up period.2.Electro acupuncture treatment can obviously improve the symptoms associated with menopause transition period, especially the heart symptoms, improve quality of life in patients with menopausal transition period and the quality of life, and has a long-term effect.3.Electroacupuncture is safe and reliable, easy to patients receiving, worth in clinical promotion. |
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