The Impact Of Systolic Pulmonary Artery Pressure On Efficacy And Prognosis In Patients With Cardiac Resynchronization Therapy

Objective Cardiac resynchronization therapy(CRT) has emerged as an effective treatment of chronic heart failure, however many factors contribute to CRT non-response. This study would explore the impact of systolic pulmonary artery pressure(PASP) in patients with CRT.Methods Patients who received CRT were enrolled in this study from June 2006 to June 2012. SAPA was assessed by Echocardiography before, one month and six months after CRT. The main endpoint events(heart failure hospitalization and all-cause death) were recorded within one–year follow-up.Results 156 patients were included in this study. Compared with normal PASP patients, left atria diameter increased with the elevated of PASP. The effect of CRT differentiated by PASP(p<0.05), decreased significantly in moderate or severe pulmonary hypertension group. Subgroup analysis found that, PASP had the trend of decrease at one month after CRT in response group, and significantly at six month after implantation, while PASP increased significantly at six month in non-response group.With the elevation of PASP, the prognosis worsed.Conclusions PASP influenced the effect of CRT significantly. With the elevation of PASP, the effect of CRT and prognosis worsed. CRT improved cardiac function, and reduced the PASP indirectly meantime.