DTI And DTT Diagnosis Of Intracranial Tumor Research And Clinical Applications

Objective:1 To investigate the clinical value of diffusion tensor imaging(DTI)and diffusion tensor tractography(DTT) showing the relationship between benign, malignant brain tumors and the surrounding white matter fiber tract.2 Diffusion tensor imaging(DTT) quantitative analysis to measure normal corticospinal tract(CST) of FDi value, FA values. And to study the correlation between the two.3 Explore the parameters of diffusion tensor magnetic resonance imaging(DTI) differences in brain tumors(meningioma, low high-grade gliomas, metastases) and its value in the diagnosis and differential diagnosisMethods: 53 cases of brain tumors: 26 cases of benign tumors, including 13 cases of benign meningiomas(WHOI grade), 13 cases of benign gliomas(WHO I-II); 27 cases of malignant tumors: including five cases of malignant meningioma( WHOII, III), 12 patients with malignant glioma(III-IV grade), 10 cases of metastases. Conventional MRI and DTI examination, the raw data were transport to the Extended MR workspace2.6.3.4 workstation.The anisotropy map(FA map), color-coded tensor and white matter fiber tract maps were obtained by using diffusion tensor data processing software(Fiber track)image analysis software package provided by Philips respectivel. the relationship between white matter and tumor was analyzed. ADC values, FA values and FDi values were measured and analyzed in regions of solid tumor, surrounding edema, adjacent white matter and contralateral normal white matter in 25 cases of glioma tumor; DTI analysis of 11 cases of healthy individuals of each parameter, and reconstruction of white matter fiber tracts, set two 2D region of interest(the base of the pons, internal capsule limb), then“Tracking Multiple a ROI of nerve fibers”generated three-dimensional tracer images of bilateral CST,bilateral CST and FA values were received by using the software to calculate the number of entries. Then“Tracking Multiple a ROI of nerve fibers”generated three-dimensional tracer images of bilateral CST,bilateral CST and FA values were received by using the software to calculate the number of entries. FA values and the significant statistical difference were measured and analyzed in regions of solid tumor, surrounding edema, tumor necrosis area in 25 cases of gliomas, 18 cases of meningioma, 10 cases of metastases tumor.Result:1 In benign and malignant tumors, displacement can occur in peritumoral white matter fiber tract.Peritumoral edema white matter fiber bundles can be expressed as edema, infiltration and sabotage.White matter fiber tracts in tumor edema mainly showed edema infiltration and destruction, Edema and infiltration occur mainly in benign, low malignant brain tumor area, the higher the degree of malignancy, the more severe the damage.2 ADC value of the low-grade gliomas and high-grade glioma tumor tumor region was higher than the ADC values of peritumoral edema; There was significant difference(P<0.05)of the ADC values between tumor area, peritumoral edema area and the adjacent white matter and normal ontralateral white matter. There was not significant difference(P>0.05)of the ADC between real tumor area and peritumorfl edema area for low-grade gliomas. The ADC values of high grade gliomas’ s solid tumor(1.256 ± 0.064× 10-3 mm2 / s) was higher than the low-grade glioma tumor(1.075 ± 0.032× 10-3 mm2 / s), and the difference was statistically significant(P<0.05). there are differences between the high-grade glioma tumor parenchyma FA values and peritumoral edema FA value, and the difference was not statistically significant(P>0.05), and the adjacent white matter and contralateral white matter FA value of two the difference was statistically significant(P<0.05) between those. Low and high grade gliomas differences tumor parenchyma, peritumoral edema and adjacent white matter contralateral white matter between statistically significant(P<0.05). The FA value of high-grade tumors parenchyma(0.223 ± 0.051) was significantly higher than the value of low-grade gliomas FA substantive area(0.175 ± 0.036), and there was a significant difference between the two(P<0.05). FDi value of Low-grade gliomas edema was higher than the high-grade gliomas, and the difference was statistically significant(P<0.05).3. FA values and the value of the fiber bundle density FDi in corticospinal tract healthy person has a positive linear correlation(r = 0.784, P<0.05).4. Different tumor diffusion tensor differences:, FA values of meningioma were significantly higher than that of glioma and metastases, glioma metastases was significantly higher than that. Tumor necrosis was no significant difference in FA values. The difference between glioma and meningioma was statistically significant,. FA values of meningioma peritumoral edema was higher than gliomas.Conclusion:1 Magnetic resonance DTI and DTT technology can better show the relationship between brain tumor and surrounding white matter fiber tracts, in a clear and intuitive, non-invasive way.2 DTI combined with conventional MRI, can help to identify different types and levels of tumors.3 FDi is a quantitative index of white matter fiber tracts and the quantitative supplement to FA value.4 Relative to the base of the MR examination, magnetic resonance DTI and DTT new technology can be used to identify normal white matter fiber and damage white matter fiber due to the tumor.