Synthesis Of Perovskite Structured Biomaterials And Their Bio-applications

Due to the unique biological compatibility, Perovskite oxide MTi O3(M=Ba, Sr, Ca) structure especially the strontium titanate which has been widely used in function in clinical medicine and tissue engineering material. This paper is devoted to study the Perovskite oxide MTi O3(M = Ba, Sr, Ca) materials modified biological scaffold materials and yolk-shell structure m Si O2@Sr Ti O3 drug control-released carrier. Their strurtcture were studied through scanning transmission electron microscopy(TEM) and electron microscopy(SEM), the X-ray diffraction(XRD). More over, Sigma assay and retention of the osteoblastic phenotype was evaluated by measuring the alkaline phosphatase(ALP) test; Cell viability was evaluated by MTT. The results were summarized as follows:Heteronanostructure of MTi O3(M= Sr and Ba) nanoparticles modified titanate nanowire scaffolds for tissue engineering have been prepared via a convenient titanate nanowire matrix assisted hydrothermal method. Different kinds of perovskite nanostructures such as heteronanostructure of MTi O3(M=Sr and Ba) nanoparticle on titanate nanowire(titanate/MTi O3), Ca Ti O3 microcube film have been successfully prepared. The Ba Ti O3 and Sr Ti O3 nanopaticles with high uniformand regular shape were implanted on the primary titanate nanowire, while the Ca Ti O3 cube film was obtained and the titanate nanowire was disappeared. The effect of Ca Ti O3, titanate/Sr Ti O3 and titanate/Ba Ti O3 scaffolds on osteoblastic cell responses were systematic investigated. These results demonstrated that Ca Ti O3 promoted cell attachment, cellular proliferation, and osteoblastic differentiation because the positive surface charge of Ca Ti O3 interacts with the negatively charged phosphate ions in the body fluid, and induce the calcium phosphate layer formation.Yolk-shell structure m Si O2@Sr Ti O3 drug control-released carriers have been developed via layer upon layer coated and choose etching method. The drug control-released carrier with the diameter of 300 nm is composed of mesoporous Si O2 kernel and Sr Ti O3 shell. The carrier has a large specific surface area and the kernel with irregular mesoporous channel, and there is a lot of space between the Si O2 core and Sr Ti O3 shell, which is advantageous to the load of drug molecules. In vitro cell culture tests revealed that this carrier has no cytotoxicity and can promote cell proliferation differentiation. Thus, this drug carrier with drug control-released and bone integration can be used as an efficient drug control-released carrier.