| Objective In order to improve medical doctors’cognition and standa rd of diagnosis and treatment of Langerhans cell histiocytosis, and decreas e misdiagnosis.Methods Clinical data of rash first option of Langerhans cell histioc ytosis in 5 patients was analyzed and summed, and related literatures asso ciated with the characteristics of clinical manifestations, pathological chang es, immunohistochemistry study feature, diagnosis and differential diagnosi s.Results The first and the second patients having systemic and unive rsale brick red papule or nodule, itching, speedy development, with lymph and blood system involvement, diagnosed multisystem Langerhans cell hi stiocytosis, Letterer-Siwe; outcome worse:the first patient improved little after chemotherapy, the second patient died two months after diagnosis. T he third and the forth patients having universale brick red papule and ves icle on the trunk and limbs, itching, gently development, without other or gan involvement, diagnosed single system Langerhans cell histiocytosis, eo sinophilic granuloma; outcome good:oral and external use treatment, no r ecurrence six months after treatment and without organ involvement. The fifth patient having brick red papule and nodule at birth, self-healing deve lopment, without other organ involvement, diagnosed single system Langer hans cell histiocytosis, congenital self-healing reticulohistiocytosis; outcome good:no recurrence two months after external use treatment and without organ involvement.Conclusion The patients who have brick red papule or nodule, with or without itching, especially infants and young children, should do skin pathologic and immunohistochemisty as soon as possible, in order to dia gnose Langerhans cellhistiocytosis early. After diagnosis systemic examinat ion are necessary for severity evaluation, multisystem damage condition is heavier, the outcome is poor, a single system damage condition is lighter, the outcome is good. |
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