Study On The Correlation Between Vascular Endothelial Growth Factor Serum Concentration And Prognosis Of Hepatocellular Carcinoma

Objective To investigate the roles of vascular endothelial growth factor (VEGF) and endostatin in the outcomes of hepatocellular carcinoma (HCC).Methods The levels of serum VEGF and endostatin(ES) were detected by ELISA in 37 patients with HCC,30 with liver cirrhosis (LC) and 32 healthy controls (HC). The relationship of serum VEGF, ES levels and the survive time was analyzed.Results The serum levels of VEGF in the HCC group were significantly higher than those in the LC and HC group (p<0.05). The serum levels of endostatin in the LC group were significantly higher than those in the HC group (p<0.05). The level of serum VEGF was negatively associated with survive time (r=-0.74; p< 0.001); the level of serum endostatin was positively related with survive time; the patients with higher level of VEGF have shorter survive time than those with lower level of VEGF(p=0.004).Conclusion The levels of serum VEGF and endostatin are increased in patients with hepatocellular carcinoma. Detections of serum VEGF and endostatin may contribute to the prognosis of hepatocellular carcinoma.