Task-related Functional Connectivity Of Nucleus Accumbens In Opiate Drug Addicts During Physical Detoxification:A Cue-elicited Task FMRI Study

Objective To analyse the brain areas having abnormal functional connectivity with nucleus accumbens in opiate drug addicts during physical detoxification with a cue-elicited task-related functional magnetic resonance imaging(f MRI), and to find out the role of nucleus accumbens dysfunction in the relapse of opiate drug addiction during physical detoxification.Methods Eighteen participants of opiate drug addicts during physical detoxification, and eighteen healthy controls performed a cue-elicited craving task in a MRI scanner while signal data was collected, after that, the left and right nucleus were selected as regions of interest(ROIs) separately, and calculated the linear correlation between the nucleus accumbens and the entire brain to find out the functional connectivity of the nucleus accumbens.Results Compared with healthy controls, the functional connectivity between the nucleus and the prefrontal cortex(46,29,-9), insula(31,25-7), posterior cingutate(4,-59,19), precuneus(4,-63,22), occipital lobe(6,71,16), lingual gyrus(11,-37,-8), calcarine(3,-45,7)in the opiate drug addicts during physical detoxification group were increased(p<0.05), the functional connectivity between the nucleus accumbens and thalamus(-8,-13,2), anterior cingutate(-2,44,20)were decreased(p<0.05).Conclusion The nucleus accumbens dysfunction of functional connectivity in a cue-elicited craving task maybe play a important role in the relapse of opiate drug addicts during physical detoxification.