Cerebellar Ataxia’s Relevant Research

Objective: To check the purkinje cell shape and structural of cerebellar atxia in mice, to pave the way for a new theoretical basis to treat spinocerebellar degeneration. Methods: Take control gourps and experimental groups of mice cerebellar for the production of paraffin. Produce section of spinocerebellar degeneration disease pathology, and our rearch chosen paraffin, we use two methods of detection: ① By HE staining of PC cells we can observed morphological changes;②Immunohistochemical detection of morphological for changes PC nucleus. Results: we can observed by HE staining of cerebellar atxia, PC nuclei have variant or missing phenomenon. we can observed by immunohistochemistry of lamin and calcium-binding proteins : PC nucleus occur various of morphological changes, a generally halo-like structure,triangular, pulled slender, or similar type of glasses were folded. Conclusion :SCA6, SCA31 type of cerebellar ataxia has relationship with purkinje cell structural changes.