| Objective:1.The purpose of this study was to explore radiation sensitivity in different tissue of eye under different radiation dose, and the damage degree from different parts of the eye on the different stages of radiation. According to the difference of the sensitivity and the damage degree, it would help us increase protection measures, as far as possibility to reduce radiation on eyeball caused by radioactive damage.2. To make more reasonable safe radiation scheme and to provide the scientific basis for assessment of therapy plan.Methods:All samples taken from our hospital were in diagnosis of nasopharyngeal carcinoma (did not meet the clinical stages III), and were low differentiated squamous carcinoma. All of the 62 cases 124 eyes of patients had taken simple radiotherapy from June 2011 to June 2014 in our hospital. All of the patients eye state and radiation treatment plan were recorded. The 14 patients 28 eyes which had begun to radiation therapy but did not complete radiotherapy cycle had been divided into two groups according to the size of the radiation dose accepted (<30 Gy and ≥30 Gy), and the damage of different eye tissues were compared. The total 62 patients 124 eyes were divided into three groups (the radiotherapy cycle group,0-6 months after radiation therapy group and 6-12 months after the radiation therapy group) according to the duration of radiation therapy, and the damage of different eye tissues were compared.Results:1. Influence of Surface of the eye in high dose group and low dose group had no obvious difference(Fisher’s exact=0.65, P=0.32). Compared high dose group with low dose group, BUT value reduced more obviously, and the difference had statistical significance(^=2.18, P=0.04). Compared to low dose group, SIT value of high dose group significantly reduced, and the difference had statistical significance(t=2.70, P=0.01).The OSDI score varied in different dose groups, The severity of dry eye increased with the addition of radiotherapy dose, which had obvious statistical significance(P<0.05). There was no difference of VEPP100between the two groups(Fisher’s exact=0.06, P=0.12).2.Compared to the radiotherapy circle group, the naked eye eyesight of 0-6 months after radiotherapy and 6-12 months after radiotherapy was significantly decreased, and the difference had statistical significance(F=12.96, P=0.04), but the corrected vision had no obvious difference(F=4.25, P=0.14). The number of cases which appeared discomfort in ocular surface was decreased by time, and the differences were significant x 2=9.08, P<0.05).Compared 6-12 months group and 0-6 months group to radiotherapy circle group, BUT value gradually extended, and the differences had statistical significance(F=8.24, P=0.04). Compared 0-6 months group and 6-12 months group to radiotherapy circle group,SIT value had a rising trend, and the differences existed statistical significance(F=7.43, P=0.04).The OSDI scores of the three groups varied, and it had statistical significance(/’<0.05). Compared 0-6 months group and 6-12 months group to radiotherapy circle group,crystalline lens was significant changed in the proportion of turbidity, which had statistical significance (χ2=8.94, P<0.05;χ2=9.47, P<0.05). Compared 6-12 months grouptoradiotherapy circle group and 0-6 months group, the amplitude increased, but the difference had no statistical significance(F=2.10, P=0.15).Compared 6-12 months group toradiotherapy circle group and 0-6 months group, the average latency obviously decreased, and the difference had statistically significant(F=6.63, P=0.03).Conclusions:The smaller doses of early nasopharyngeal carcinoma radiotherapy could affect the stability of tear film. With the addition of radiotherapy dose, the eye got nore severe damage. Part of the eye complications was gradually restored with the extension of time. Crystal and optic nerve had a high radiation sensitivity, which needed... |
PDF Full Text Request