Discussion Of The Diagnosis And Treatment Of Pulmonary Diseases Characterized By Ground-glass Opacity Of CT

Background:In the 21 st century, with the development of Computed Tomography(CT) and Positron Emission Computed Tomography(PET),as well as the universalization of health examination,the number patients whose lung is characterized by ground-glass opacity of CT was much higher. ground-glass opacity of lung refers differ and high-density shadows of CT and that Pulmonary bronchial or pulmonary vessels are visible. Multiple of pulmonary diseases are characterized by ground-glass opacity of CT, such as early lung cancer, pneumonia, alveolar hemorrhage, pulmonary atypical adenomatous hyperplasia.CT is the main method of radiography. we can identify the small lesions and fine structures of lung and analyze the size, location and other aspects of morphology of GGO. FDG-ET is a diagnostic indicator of malignancy and distinguish the benign and malignant lesions. Current treatment of GGO lesions is mainly surgery. Appropriate surgical approach is selected according to size, location, radiological, pathological characteristics of lesion and lymph node metastasis. The surgical approach contains sub-lobectomy including(lung wedge resection and lung resection) and lobectomy. We need to locate the lesions of GGO in Hookwire way to improve the success rate because of the invisible and inaccessibility lesions during operation.Methods : 42 patients with pulmonary diseases characterized by ground-glass opacity were collected from the first people’s hospital affiliated to soochow university from 2013.01 to 2014.12. 13 of them are male and the other 29 are female. The ages are from 43 to 80 and the average is 61. Clinical manifestation : Chest pain symptoms in 4 cases, 5 cases of recurrent cough symptoms, 33 cases without obvious symptoms; Lesion size: less than 1cm in 11 cases, 19 cases of 1-2cm, more than 12 cases of 2cm; Lesions: mixed GGO in 14 cases, pure GGO in 28 cases; surgical approachs: simple wedge resection in 21 cases, 2 cases of lung resection, lobectomy in 19 cases, of which 9 cases of preoperative localization in hookwire way; Pathology: adenocarcinoma of lung in 24 cases, AHH in 9 cases, 9 cases of inflammatory diseases, including 2 cases of granulomatous inflammation. The cases were divided into two groups(benign and malignant) to study the correlation of the sex, age, symptoms, size of lesions, property of lesions using SPSS 17.0.Result : 9 cases were divided into the benign group(inflammatory fibrosis and granulomatous inflammation) and 33 cases were divided into the malignant group. The malignant rate is 78.57%, which is as same as the reports before. It had no statistical differences among the groups of sex, age, symptoms(p>0.05). Most of the tumors whose size is equal or greater than 1 cm are malignant(χ2=9.729,p=0.008); Most of the GGO whose property is mixed are malignant(χ2=5.727,p=0.017<0.05)。Conclusion : 1.Gender, age, and clinical symptoms of the clinical treatment of GGO without clinical significance; 2.GGO diameter is greater than or equal to 1cm of the patients should undergo surgical operation as soon as possible; 3.The patients with mixed GGO should be treated with surgical operation as soon as possible.