Mechanism Of Antt-atherogenesis Effect Of Shikimic Acid From Illicium Verum

Objective:To investigate the effects of shikimic acid on antioxidation ability,inflammatory factors and s PLA2- Ⅱ A m RNA in atherosclerosis rats.Methods Seventy-two Wistar rats(n=12/group) were randomly divided into six group,the normal goup,the model group, the Simvastatin group, high shikimic acid group(60 mg.kg-1), middle shikimic acid group(30 mg.kg-1) and low shikimic acid group(15 mg.kg-1). Atherosclerosis rats were induced by injected with asingle dose of vitamin D(600000 IU.kg-1)and loaded with high fat diet in order to copy the model. After 24 weeks administration, the serum superoxide- dismutase(SOD), malonicdialdehyde(MAD), tumor necrosis factor(TNF-α)and s PLA2-ⅡA m RNA were observed. Results Compared with that of normal control group, the serum level of shikimic acid of TNF-α,CRP and MDA of model group was remarkably increased,the actixity of SOD and m RNA expression of s PLA2-ⅡA were inhibited(P<0.01,P<0.05), Shikimic acid could reduce the level of serum CRP and TNF- α from(10.82 ± 4.33)mg.L-1 and(49.88±22.91) ng.L-1 of the model group to(8.17±1.74)mg.L-1and(28.18 ± 15.95) ng.L-1(P<0.05).reduce the level of serum MDA from(21.55 ± 4.45) nmol.ml-1 of the model group to(18.70 ± 1.95) nmol.ml-1(P<0.05),and improve the activity of SOD from(145.81±50.61) U.m L-1of the model group to(199.87±50.291) U.m L-1(P<0.05),, and inhibit the expression of s PLA2-ⅡA m RNA(P<0.01).Conclusion Shikimic acid can reduce the level of inflammatory factors, improve antioxidation ability, and inhibit the expression of s PLA2-ⅡA m RNA.