The Effect Of Different Modes Of Peritoneal Dialysis Treatment To The Hemodialysis Patients’ Calcium Phosphorus Metabolism And PTH

Objective:To investigate and compare the changes in calcium and phosphorus metabolism and parathyroid hormone (PTH) in patients who underwent DAPD and those who underwent CAPD. Methods:83 patients, aged 45.26±16.14, were selected from 160 eligible patients who underwent PD at the Nephrology Division of the People’s Hospital of Xinjiang Uygur Autonomous Region and divided into two groups, based on different dialysis modalities as CAPD (n=54, F/M=33/21) and DAPD (n=29, F/M=16/13) groups. Dialysis dosage per time for CAPD group was 6L-8L, which was exchanged for 3 times after 5h interval diurnally and once nocturnally and maintained for 9h (nocturnal dialystae concentration:1.5%). Under the same dialysis dosage, DAPD group underwent exchange only diurnally for 4 times with 4h interval and evacuate the dosage nocturnally. Then, baseline characteristics, serum hemoglobin, calcium, phosphorous, parathyroide hormone, albumin, creatinine, triglyceride, blood urea nitrogen, ultrafiltration volume and residual renal function of the two groups were compared. Results:No significant difference was observed in terms of baseline characteristics (P>0.05); whereas hemoglobin, albumin, creatinine, calcium, phosphorous parathyroide hormone and 4h ultrafiltration volume were significantly different between two groups (P<0.05); Residual renal function before and after one-year of dialysis was significantly different between groups (P<0.05). Conclusion: metabolism in calcium, phosphorous and parathyroid hormone metabolism and residual renal function in DAPD group was significantly modified, compared to CAPD group. Treatment with DAPD might have advantage over the CAPD.