| Objective:To explore the clinical significance and correlation of serum amino-terminal pro-brain natriurelic peptide (NT-Pro BNP), Troponin, the D-Dimer and levels in patients of Acute pulmonary embolism (APE) with pulmonary hypertension (PH).Methods:Eighty eight patients with APE were measured pulmonary artery systolic pressure (PASP) by echocardiography. They were divided into 3 groups according to PASP:no PH group (<30mmHg) 37 cases, mild PH group (30-60mmHg) 22 cases and moderate-severe PH group (>60mmHg) 29 cases. Serum NT-Pro BNP, Troponin, D-Dimer levels and arterial blood gas analysis were detected from all the selected patients.Results:PASP was closely associated with risk stratification (r=0.462, P=0.002); PASP was no obviously associated with gender, age and heart rate; Serum NT Pro BNP, P02> Troponin and D-Dimer are all great different in three groups in all patients (P<0.05); SerumNT-Pro BNP in APE with moderate-severe PH group and mild PH group were significantly higher than the no PH ones (P<0.01); Serum NT-Pro BNP in APE with moderate-severe PH group were significantly higher than the mild PH ones (P<0.01); Serum D-Dimer in APE with moderate-severe PH group were significantly higher than the no PH ones (P<0.05); Serum Troponin in APE with moderate-severe PH group were significantly higher than the mild PH group and no PH ones (P<0.01); While Serum PaO2 in APE with moderate-severe PH group and mild PH group were significantly lower than the no PH ones (P<0.05); NT-Pro BNP, Troponin and D-Dimer were observed a significant positive linear relationship between PASP ((r=0.746, t=7.764; r=0.389, t=2.990; r=0.427, t=2.618; P<0.01); We also found that PO2 was negatively ° correlated with PASP (r=-0.436, t=-3.419, P<0.01).Conclusion:Serum NT-Pro BNP, Troponin and D-Dimer levels are closely related to the PASP, and can be used as indicators to judge these verity of PH in of APE patients. |
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