| ObjectiveTo comprehensively evaluate positron emission tomography/ computed tomography in follow-up of ovarian cancer and on patient management with the suspected recurrence by the help of evidence-based Meta-analysis.MethodsWe searched the databases from CNKI website, Wan Fang website, PubMed database (Medline database), Cochrane Library, Embase database about PET/CT in the follow-up of ovarian cancer and on patient management with the suspected recurrence. The study is limited to "human", time table is January 2005 to December 2014. Follow the rigorous inclusion and exclusion criteria in collecting documents, exclude the articles that mismatch the research purpose and the QUADAS quality requirements. According to the evidence-based diagnostic tests Meta-analysis method using Meta Disc 1.4 software to depict ROC curve and determine the heterogeneity of the study and their sources, select the appropriate model merge sensitivity (SEN), specificity (SPE), positive likelihood ratio (+LR), negative likelihood ratio (-LR), diagnostic odds ratio (DOR) and other indicators, and draw forest plot and the receiver operating characteristic curve (SROC curve) and calculate the area under the curve (AUC).ResultsOur study were obtained 427 literature at first, and ultimately included 25 documents diagnostic tests,16 in English,9 in Chinese. There are 21 literatures on patient in our study which including 1289 cases; and 6 literatures focus on lesions which have 1347 cases.1. PET/CT as a diagnostic test in patient study of SEN is 0.92, SPE is 0.91,+LR is 6.53,-LR is 0.10, DOR is 81.95, AUC is 0.9574;2. PET/CT as a diagnostic test focus on lesions study of SEN is 0.89, SPE is 0.95,+LR of 7.87,-LR to 0.15, and DOR is 64.12, AUC is 0. 0.9487;3. US as a diagnostic test in patient study of SEN 0.63, SPE is 0.94, +LR is 9.26,-LR is 0.40, DOR is 23.45;4. Enhanced CT of pelvic in the diagnosis test SEN was 0.78, SPE is 0.79,+LR is 3.1,-LR is 0.24, DOR is 23.45;5. Pelvic MRI in the diagnosis test SEN was 0.74, SPE is 0.91,+LR is 7.49,-LR is 0.25, DOR is 38.81.Conclusion1.PET/CT in the diagnosis of recurrent ovarian cancer have a higher accuracy of sensitivity, specificity and diagnostic;2.PET/CT in ovarian cancer follow-up, recurrence diagnosis accuracy, sensitivity, and specificity superior to conventional imaging (US, CT, MRI);3. PET/CT fin recurrent ovarian cancer clinical decision instructive. |
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