Risk Factors Of Contrast-induced Nephropathy In Patients Undergoing Coronary Intervention And The Clinical Significance Of Changes In Urinary NGAL

Objective：To observe degree rise in creatinine levels after coronary artery interventional.To exploreclinical risk factors for different degrees contrast-induced nephropathy and the clinical significance of urineNGAL.Methods：(1)Select coronary angiography and interventional treatment were157patients..According tothe creatinine level of2to3days was divided into4groups:The normal group, group of renal damage1:Creatinine0-10%,group of renal damage2:Creatinine10-25%,group of CIN: creatinine≥25%.(2)Evaluation of risk factors between4groups. Detected urine NGAL after12hours and the clinicalsignificance of urine NGAL.(3)All data were analyzed using t test,X2test and correlation analysis.Significance was set at P<0.05.Results：(1) CIN occurred was8.9%.There were significant difference in left ventricular ejection fraction（X2=13.3，P=0.004），albumin levels（F=2.76，P=0.044），preoperative creatinine（X2=10.14，P=0.017）,postoperative creatinine (X2=28.96，P＜0.01），the dose of contrast agent （X2=26.2，P＜0.01）.(2) Logistic regression analysis indicated that the dose of contrast agent and hypoalbuminemi（OR=13.47，95%CI3.33-54.48，P=0.001；OR=1.778，95%CI1.076-2.93，P=0.025) were the risk factorsfor CIN.(3) There was a significant difference of determination of urinary NGAL in CIN group.There wasno difference in other groups.Conclusion：Dose of contrast agent and hypoalbuminemia were two risk factors of CIN.urine NGALtesting After12hour can be used as an indicator of CIN assessment.