| ObjectiveDelayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is adisease with high incidence, complex and unclear pathogenesis, poor prognosis andindefinite therapy. In this study, explore cord blood stem cells transplantation the clinical ofDEACMP, for the clinical treatment of DEACMP to provide the theory basis.MethodUsing retrospective analysis,62DEACMP patients hospitalized in Neurology ofLiaocheng People’s Hospital from December,2010to June,2013was chosen. Thesepatients were divided into two teams,30received cord blood stem cell transplantation andconventional drug treatment as the treatment group, and the other32received hyperbaricoxygen therapy and conventional drug treatment more than20days as the control group.During the course of treatment, every patient was examined through Mini Mental StateExamination (MMSE), Aimaging examinationivities of Daily Living (ADL) score andBrain imaging examination respeively before and after treatment. All the patients werefollowed up six months continuously to observe their prognosis and the existence ofadverse reaimaging examinationions. The statistical analysis of the two samples wascarried out using t-test, variance analysis and chi-square test.Result1. There was no special discomfort during the cord blood stem cell transplantation ofpatients in the treatment group. In the operation and24hours later, their vital signs werestable, without any fever, punimaging examinationure point infeimaging examinationion,bleeding, etc. In the outpatient follow-up after surgery, there was no transplant-relatedcomplication.2. Both the MMSE and ADL scores of the two groups of patients before and after treatment has significant difference, with statistical significance (P<0.05), and there was nosignificant difference among the group before treatment (P>0.05).3. Six months later, the MMSE score of patients in the treatment group (22.83±5.28)was higher than that of the control group (9.81±7.40, t=4.199, P=0.0003), with statisticallysignificant difference (P<0.05).4. The ADL score of patients in the treatment group (80.5±17.34) was higher than thatof the control group (35.78±28.34, t=4.478, P=0.0002), with statistically significantdifference (P<0.05).5. The improvement rate of IMAGING EXAMINATION examination result ofpatients in the treatment group (93.33%) was higher than that of the control group(21.88%), with statistically significant difference (χ2=4.402, P=0.0359).6. The clinical cure rate of patients in the treatment group (53.33%) was higher thanthat of the control group (6.25%), with statistically significant difference (χ2=4.055,P=0.0442). The clinical efficiency of patients in the treatment group (96.67%) was higherthan that of the control group (46.88%), with statistically significant difference (χ2=5.866,P=0.0154).Conclusion1. in the treatment of DEACMP, there is improvement of cognitive funimagingexaminationions and increase in the aimaging examinationivities of daily living in bothgroups.2. The assessment of the indexes of the treatment group was better than that of thecontrol group, which means that the application of cord blood stem cell in improvingcognitive funimaging examinationions and aimaging examinationivities of daily living hasa better effeimaging examination.3. The clinical efficacy of the treatment group is better than that of the control group,which means that cord blood stem cell could be used in the clinical treatment of DEACMPinstead of conventional hyperbaric oxygen therapy. |
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