Analysis Of Polymyositis And Dermatomyositis Associated Interstitial Lung Disease And

Objective To investigate the clinical characteristics of polymyositis(PM) and dermatomyositis(DM) associated interstitial lung disease(ILD), explore the related factors in PMand DM with ILD.Methods To collected data of92cases patients with PM and DM hospitalized in Division of Rheumatology of The Frist Affiliated Hospital Of GuangXi Medical University from October2010to October2013. Retrospective comparison and analysis of the first symptoms,clinical and immunologic features were performed between PM/DM associated interstitial lung disease and patients without associated interstitial lung disease. Process the data using SPSS19.0software, measurement data using t test, count data using percentages description,χ2test analysis. Analysis of related factors using Logistic regression. All results are expressed P<0.05was considered statistically significant.Results Among92cases patients with PM and DM hospitalized in Division of Rheumatology of The Frist Affiliated Hospital Of GuangXi Medical University from October2010to October2013, with interstitial lung disease was37cases, the rate was39.8%. Gender differences in the composition of the two groups were not statistically significant (P>0.05). Comparison of age between patients with interstitial lung disease with the group without interstitial lung disease, the average age in the group with interstitial lung disease is higher than the group without interstitial lung disease,the difference is statistically significant (P<0.05). Between the patients with interstitial lung disease with the group without interstitial lung disease, the initial symptoms of cough, shortness of breath and fever,difficulty swallowing in the before one is higher than the behind one,and the differences is statistically significan.The incidence of face purple spots, myalgia, muscle weakness, arthralgia, Gottron incidence of rash was no significant difference. aboratory examination of patients with ILD group elevated erythrocyte sedimentation rate, anti-Jo-1antibodies were higher than without ILD group, and ECG showed myocardial change, EMG showed myogenic changes in muscle enzyme (CK, CK-MB, ALT, AST, LDH) increased in both groups had no significant difference. Logistic regression analysis showed that factors cough,wheezing, difficulty swallowing, fever, erythrocyte sedimentation rate, anti-Jo-1antibody positive, age was positively correlated with ILD (P<0.05). The face purple spots incidence in patients of typical dermatomyositis is higher than the incidence of Amyopathic dermatomyositis. Compared with The face purple spots Joint pain in the two group Performance Inverse relationship. While ANA antibodies, Gottron papules no significant difference in the two groups (P>0.05). Using Inspection of HRCT in PM/DM patients with ILD can earlier discovery lung disease in early stage. The significant of Using hormone therapy combined with cyclophosphamide is better than single hormone or hormone combination with methotrexate, azathioprine in patients with DM/PM-ILD, the difference was statistically significant (P<0.05).The patients of PM and DM have differences clinical manifestation,and pathogenesis is inconsistent.When they combined with ILD, the incidence of muscle pain, weakness, fever, arthralgia, and dysphagia was no significant difference.Conclusions ILD is a common complication of DM/PM, cough, shortness of breath, fever, difficulty swallowing, and anti-Jo-1antibody positive, high levels of erythrocyte sedimentation rate is related to the occurrence of ILD factors of DM/PM. Amyopathic dermatomyositis is a special type of dermatomyositis,The arthralgia incidence is higher than the typical dermatomyositis,,and purple spots appear face low incidence. Using Inspection of HRCT in PM/DM patients with ILD can earlier discovery lung disease in early stage. The significant of Using hormone therapy combined with cyclophosphamide is better than single hormone or hormone combination with methotrexate, azathioprine in patients with DM/PM-ILD. In PM and DM patients with with ILD, the incidence of muscle pain, weakness, fever, joint pain and dysphagia was no significant difference.