Different IVF Techniques And Their Associations With Hypertensive Disorders In Pregnancy

OBJECTIVEAnalyze the characteristics of infertile population who received IVF techniques, and explore the association between different IVF techniques and hypertensive disorders in pregnancy.METHODSCollect inpatient data from ART (Assisted Reproductive Technique) department and obstetric department in Affiliated Women’s Hospital of Zhejiang University School of Medicine. Retrospectively compare683infertile patients who received IVF technique as an assisted reproductive method and thereafter succeeded in ’taking baby home’. Calculate the prevalence of hypertensive disorders in pregnancy in groups of patients receiving different IVF techniques. RESULTSIn all683cases,391(57.2%) received regular IVF technique, and the remaining292(42.8%) received ICSI for oocyte fertilization.463(67.8%) received fresh embryo transfer, and the remaining220(32.2%) received frozen-thawed embryo transfer.58cases (8.5%) developed hypertensive disorders in pregnancy, among which22(3.2%) had pregnancy-induced hypertension,35cases (5.1%) presented as preeclampsia, and only1case (0.1%) developed eclampsia. Course of infertility was significantly associated with pregnancy-induced hypertension (OR1.16,1.04-1.30). Body Mass Index was significantly associated with preeclampsia (OR1.16,1.03-1.30). Within twin mothers, ICSI group showed increased risk of pregnancy-induced hypertension against IVF group, the OR being5.27(1.07-26.0), multivariate-adjusted OR attenuated to4.47(0.87-22.96). In singleton mothers, ICSI showed no significant association with hypertensive disorders in pregnancy. FET (Frozen-thawed embryo transfer) group showed no increased risk of pregnancy-induced hypertension, and the OR being0.46(0.15-1.37), multivariate-adjusted OR being0.51(0.17-1.54). FET group also showed no increased risk of preeclampsia, the OR being0.96(0.46-2.00), multivariate-adjusted OR being1.00(0.47-2.09).CONCLUSIONICSI fertilization technique may increase the risk of pregnancy-induced hypertension. Whether or not the embryos receive freezing and thawing process before transfer is not associated with pregnancy-induced hypertension. The mechanisms underlying these associations require further prospective studies and basic studies.