Effect Of Neoadjuvant Chemoradiotherapy On Anastomosis And Defuctioning Stomas

Objective To investigate the effect of the neoadjuvant chemoradiotherapy(NCR) on the anastomosis and defuctioning stomas following low anterior resection in patients with rectal cancer.Methods Between May2008and May2013,119patients with T1-4rectal cancer in Sir Run Run Shaw Hospital of Zhejiang University enrolled in the study.They were divided into two groups. Group A consists of66patients who were subjected to preoperative radiotherapy to pelvis, with a total does of44-46Gy in20days fractions of2Gy each in4weeks, all received5-FU-basedchemotherapy during the period of radiotherapy. Low anterior resection(LAR) was performed6to8weeks after completion of neoadjuvant therapy according to the role of TME technique. Group B consisted of53patients who without preoperative radiotherapy got surgery directly. All patients got defuctioning ileostomy.Results Anastomosis-related complication was16.7%in group A and6.7%in group B, without significant difference(P=0.064). Defuctioning ileostomy became permanent stoma was16.7%in group A and15.1%in group B, without significant difference(P=0.895).Conclusion Preoperation neoadjuvant chemoradiotherapy has no impact on Anastomosis-related complication and defuctioning ileostomy became permanent stoma.