Sequential Therapy For The Adherence Of Helicobacter Pylori Infection In Children And Its Curative Effect Analysis

Objective To investigate the sequential therapy for Helicobacter pylori(H pylori)eradication in children to assess the compliance and efficacy of sequential therapy.Methods (1) Methods Children with upper gastrointestinal symptoms whotested positive for H. pylori were randomly divided into two groups (sequential therapy108cases,96cases of triple therapy), conducted a questionnaire survey, and to analysisof compliance factors on different therapies.(2) Children with upper gastrointestinalsymptoms who tested positive for H． pylori by13C-urea breath test （13C-UBT）were randomly divided into sequential therapy group and triple therapy group.Sequential therapy group was treated by amoxicillin and clavulanate potassium for thefirst five days，followed Omeprazole, clarithromycin, amoxicillin and clavulanatepotassium for the next five days．And, triple therapy group was treated by amoxicillinand clavulanate potassium for the14days. After the end of treatment, a month later, allchildren was tested for13C-UBT, and analysis of treatment efficiency and HPeradication rates.Results⑴Adherence questionnaire: sequential therapy group parents answer thequestion "Adverse reactions occur during medication yet," the proportion (24%) lowerthan the triple therapy group (43.7%), respectively, the differences were statisticallysignificant (P <0.05). In response to "Can children receive medication " and "Can youaccept this treatment," when these two issues, the proportion of parents of children withsequential therapy (82.4%,75.9%) were higher than the triple therapy (72.9%,59.3%),respectively, the differences were statistically significant (P <0.05).⑵Completion rate:sequential therapy group and the triple therapy group were three cases and two caseswere lost, there were five cases and12cases midway self-withdrawal, the two groups was89.33%completion rate and82.72%respectively, the difference was notstatistically significance (P <0.05).⑶Efficiency: sequential therapy group and thetriple therapy group efficiency of94.03%and80.60%respectively, and the differencewas statistically significant (P <0.05).⑷HP eradication rate: sequential therapy groupand HP eradication rate of triple therapy group was94.03%and58.21%respectively,and the difference was statistically significant (P <0.05).⑸Incidence of adversereactions: sequential therapy group and the incidence of adverse reactions triple therapygroup was10.45%and14.93%respectively, the difference was not statisticallysignificant (P>0.05).Conclusions The10-day sequential therapy in compliance, efficiency anderadication Sequential is better than standard14-day triple therapies in eradication ofH.pylori infection. The sequential therapy may be associated with higher treatmentadherence because of five days shorter and fewer drug-related.