Numerical And Experimental Investigation On The Effects Of Nanoparticles Size On Targeted Drug Delivery

With the development of the times and the improvement of science and technology, peopleovercome many diseases.But there are still not effective treatment of some diseases, such ascardiovascular disease and cancer.The researchers found that many are effective in the treatment ofcardiovascular disease, cancer and other diseases of the polymer through a variety of expensiveexperiments, but due to the lack of selective and targeted transport of these polymer reaches thedesignated position way, and do not cause or minimize the damage to other biological tissues, thesepolymers are far from application to clinical.People want to find such a drug loading "vehicle", itcan avoid the body obstacles, and eventually delivery of the agent to the specified location.At thepresent stage, through the tiny particles (such as nano) to targeted drug delivery or transmissionimaging agent technology is currently a research hotspot in the world, this technology hasfar-reaching significance in cancer detection and therapy.This paper aiming at the problem and made a preliminary theoretical calculation. Firstly,simplified the vessel model;Then, made a force analysis of micro particles in fluid and establishedmathematical model through the balance between the force and moment;Then using MATLABanalysed the relationship among the force of micro particles,the size of micro particles and flux, andsolved mathematical model; Finally, built an experimental system, and verified the reliability oftheoretical calculation.This thesis is divided into6chapters. The main contents of each chapter are as follows:Chapter1described the background and significance of the research, detailed introduced themicro particulate drug carriers present research situation at home and abroad, and put forward themain contents of this thesis.Chapter2built the mathematical model.Firstly simplified the blood fluid into Poiseuille Basedon the study of blood flow of the predecessors and accorded to the features of blood flow, at thesame time for the vascular wall which is simplified as a parallel plate flow chamber.So wesimplified the vessel model, and established a physical model of a relatively simple.Then this paperanalyzed the stress situation of micro particles in a fluid, listed the calculation formula of all kindsof force,and built the mathematical model which is the relationship among the Reynolds number ofmicro particle,micro particle diameter and injection flow according to the equilibrium condition offorce and torque.Chapter3analyzed the size of force of micro particles in the fluid. Using matlab analyzed the relationship among the size of force, micro particle diameter and flux, and drew their curvediagram.Chapter4solved the mathematical model. Using matlab drew the curve diagram about therelationship among the Reynolds number of micro particle,micro particle diameter and flux.Weobserved and analyzed the curve diagram, and has drawn a conclusion.Chapter5built an experimental system, and verified the reliability and correctness oftheoretical calculation. Aiming at theoretical research, we built a special experimental system, drewthe conclusion, and verified the correctness of the theoretical calculation.Chapter6carried on the summary to the full text, and pointed out the deficiencies in thecalculation process and experiment and improvement direction.