The Effect Of Combination Resveratrol With Zidovudine On Immunosuppressive Mice

Objective:To investigate the immune reconstruction function effect of combination Resveratrol with AZT on the immunosuppressive mice caused by cyclosporine A. Methods:The immunosuppressive mice model is established by intraperitoneal injection of cyclosporine A. The experiment is divided into combination group, Resveratrol group, AZT group, Zhen Qi group,model group, solution group, blank group.Observe the following target after one week:The weight index and pathological changes of the spleen and thymus;The detection of CD4+T, CD8+T lymphocyte subsets and ratio. Results:1. The weight index of thymus:Compared blank group and control group, the thymus weight index of model group was decreased(P<0.05).Compared with model group, the thymus weight index of combination group and Resveratrol group was increased apparently(P<0.05).2.The pathological changes:Compared blank group and solution group, the model group of spleen white medullary portion of enlarged and there has many multi-core macrophages; thymus atrophy and cortical thickening.Combination group and Resveratrol group were improved apparently.3.T lymphocyte subsets:Compared blank group and solution group, the proportion of model group CD4+,CD8+T lymphocyte and ratio was decreased(P<0.05).Compared with group, combination group and Resveratrol group of CD4+,CD8+T lymphocyte was increased (P<0.05, P<0.01). Conclusion:Combination group and Resveratrol group have immune reconstitution function on immunosuppressive mice model established by intraperitoneal injection of cyclosporine A.