Research Of Prediction Of MI/RI Chinese Herbal Compound Targets Based On Complex Networks

Chinese medicine is a long history of medicine, is a great treasure. Five thousand years of Chinese culture documented in an irreplaceable role in the treatment of disease. In recent years, Chinese medicine in the face of some new disease when it was found to have a lot of irreplaceable role in modern medicine. A large number of national studies have shown that extracts of traditional Chinese medicine and has good inhibition of cardiomyocyte apoptosis, is being applied to myocardial ischemia-reperfusion injury and achieved remarkable results. In recent years, the use of complexity science to study traditional Chinese medicine theory made a lot of achievements. By complexity and nonlinear science provides new ideas and methods to excavate connotation of Chinese medicine. Complex networks is a complex science is an important way to express his abstraction of complex systems is described. In general, the study of complex network is the composition contains a large number of units (or subsystem) of a complex system, is abstracted as a node constituting units in the system, the relationship between the cell edge is abstracted; complex network is of complex an angle and systematic approach, which concerns the topology of interconnected systems of individual action, is to understand the nature and function of complex systems basis. According to the characteristics of Chinese medicine prescription system, capable of complex networks as a starting point to study it. Our research in this area is just beginning to study this aspect is gradually increasing. However, the application of complex networks to research myocardial ischemia-reperfusion injury is still relatively small. Currently, the complex network applications in medicine medicine primarily targets identification, based on the pharmacological effects related links and index-based traditional Chinese medicine theory and the efficacy of traditional Chinese medicine and Chinese medicine basics of molecular networks, networks and the concept of network modules; excavation syndrome, treatment the relationship between law and medicine; complex network of a large number of indicators in the core positioning research.This article is based on myocardial ischemia-reperfusion injury in the target information on the role of the target, and the component of traditional Chinese medicine and other information related to the construction of a network to do the research. By building a network to integrate all the information, the use of complex network theory and tools to dig out hidden information researchers can not easily be found.1PurposeIn this study, myocardial ischemia-reperfusion injury for the demonstration through the integration of information and the establishment of a complex network model to explore the role of reasoning compound targets. Provide clear reference target for drug research, drug discovery and development of new models in order to widen and shorten drug development time. Followed by a multi-component multi-target, multi-path research trends, but also provide a reference for the experimental study.2Research methods and content①determine the data sourcesBy Tsinghua Tongfang, Articles, VIP database to compare the advantages and disadvantages. According to Tsinghua Tongfang included more than the number of magazines and most comprehensive advantages search field, select the database to Tsinghua Tongfang is one data source. Because since2007, Chinese Medicine Articles exclusive series of magazine issued WanFangDATA also select the data source. But in order to avoid duplication, in Articles download only since2007, the medical journal of the Chinese family related articles.②developed information extraction principle, the establishment of targets (path)-a compound (single herb) NetworkAccording to the content of the research, namely the intervention of myocardial ischemia-reperfusion injury in medicine or compounds extracted, while the effect of drugs or compounds targeting signaling pathways and extraction. Establish targets (path)-a compound (single herb) network.③collecting associated natural medicine, the establishment of the compounds-natural medicine networkCompound used in the experiment was the object of intervention MIRI, through the "People’s Republic of China Pharmacopoeia", Chinese chemical composition databases to collect the natural medicines containing the above compounds. Established compounds-natural medicine network.④use Cytoscape modelingDepending on the circumstances of the study, the use of natural medicines Cytosacpe build-compounds (single herb)-target (path) of complex networks. Connecting principle between nodes is the same, then associate a target compound or compounds and natural medicines produced by the action of a passage contained in the role of the object and natural medicine. At the same time, and the description and analysis of the overall network.⑤Select the results have been clear to validate the network model compoundChinese herbal compound contained in the target node, select the points in the network model, has a relationship with these nodes to extract sub-networks. Target information analysis for sub-networks that appear feasible intervention in myocardial ischemia-reperfusion injury.3ResultsIn this paper, the use of complex network theory and experimental data extracted to build the target-the network components, and draw the target-component network diagram. Using professional database-related data to build a component-Chinese network, and draw the ingredients-Chinese figure. By association of these two networks constitute a new target-ingredients-Chinese network diagrams, analyze their network connectivity and clustering coefficient. Verify the chest through a small trap Tonga flavor and DXR found the target with the experimental network putative target is coincident.4ConclusionsFirst, this paper build targets-network components, ingredients-Chinese network, target-ingredients-Chinese networks, and network visualization and analysis. Relationship can be derived complex network approach between research and drug targets, and then infer the possible target group side.Second, Xiaoxianxiong decoction and DXR example, Xianxiong decoction and DXR experimentally derived data and data network diagram drawn by comparing the presumed small, illustrates the use of the network to predict a target with a certain feasibility. With guidance and reference in the study of new drugs.