Study And Clinical Significance On The Deep Gray Matter Involvement Of Magnetic Resonance Imaging In Multiple Sclerosis

Objective:By observing the lesion characteristics of multiple sclerosis patients’ brain deep gray matter nuclei (putamen, caudate nucleus, thalamus, globus pallidus, red nucleus, etc) in T2-weighted imaging, SWI and T2mapping scan, and then quantitative study the iron deposition of MS gray in the deep, observe the distribution of iron deposits, finally study the correlation between the deep brain gray matter nuclei changes of multiple sclerosis patients and clinical EDSS scores and cognitive dysfunction. Materials and methods:According to the McDonald2010diagnostic criteria we collected20cases of relapsing-remitting multiple sclerosis(RRMS) patients with multiple sclerosis visiting the China and Japan union hospital of Jilin university during September2013to September2014which make up of the patients group, the control group consists of20healthy volunteers whose ages are matched with the patients group. Both groups had signed the informed consent forms, and then have an MRI magnetic susceptibility-weighted Imaging examination SWI image. Using the SPIN software measure the deep gray nuclei of average phase value of every patient. Both groups of patient with multiple sclerosis also accept the mini mental state examination (MMSE) evaluation, the expanded disability status scale (EDSS) score. Expanded disability status scale (EDSS) score, to assess the degree of cognitive impairment and neurological deficits.Results:1. Compared with the control group, group of MS patient with deep gray matter nuclei have reduced in T2signal value. This change in black mass on the left side, the left putamen and caudate nucleus T2signals of the head to the right value have significant differences.2. Compared with the control group, the phase diagram of the deep gray matter signal of patient group have general low phase values, but only the average phase value of the substantia nigra of bilateral differences of control group (P<0.05), and the other deep grey matter structures are not;3. In comparison with the control group, deep gray matter nuclei the R2value shows an increased tendency, black mass on the left side, the left putamen, thalamus higher R2values on the right side, these have statistically significance (P<0.05);4. The EDDS and MMSE scores of deep gray matter phase values of the patient group showed no significant correlation(P>0.05). With the exception of Red nucleus on the right side of the phase values with EDSS scores were negatively correlated (r=-0.580, P=0.007), the right caudate nucleus and MMSE scores were positively correlated (r=0.499, P=0.025).5. In bilateral globus pallidus and left the Red nucleus the R2value SWI phase values shows negative correlation, P<0.05, has statistically significance. Left globus pallidus R2value linear regression P<0.01with the SWI phase value, there was a significance statistically difference, R2=0.631, fitting better. Conclusion:1.Deep gray matter lesions and various degrees of abnormal iron deposition exist in multiple sclerosis.2.Deep gray matter iron deposits associated with neurological dysfunction.3.SWI helped to improve the pathologic features of live grey matter lesions in multiple sclerosis, by using SWI phase values of quantitative study on the determination of iron content in brain of multiple sclerosis patients, contribute to the assessment of MS patients and monitor changes.4. R2relaxation rate and T2signal, phase diagram, value can reflect iron deposits in a certain degree. But R2values are more sensitive.